Anti-Cancer and Anti-Inflammatory Activities of Bromo- and Cyano-Substituted Azulene Derivatives

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dc.authoridInce, Mine/0000-0002-9164-0446
dc.authoridYUZER, ABDULCELIL/0000-0002-2287-4126
dc.authoridince, tuncay/0000-0002-5150-3463
dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.contributor.authorAyaz, Furkan
dc.contributor.authorYuzer, Abdulcelil
dc.contributor.authorInce, Tuncay
dc.contributor.authorInce, Mine
dc.date.accessioned2025-03-17T12:27:37Z
dc.date.available2025-03-17T12:27:37Z
dc.date.issued2020
dc.departmentTarsus Üniversitesi
dc.description.abstractNatural products and their synthetic derivatives gathered attention due to their pharmaceutical capacities. They have been in use against different types of diseases ranging from cancer to inflammatory disorders. In order to increase their efficacy and prevent the possible side effects, these natural compounds are manipulated at the laboratory conditions and modified according to our needs. Azulene is one of these compounds whose anti-inflammatory potential have been shown by the previous studies, but a detailed analysis of its effect at the cellular level in terms of pro-inflammatory cytokine production has not been studied yet. Moreover, its derivative potential has not been characterized extensively. In our study, we examined the cytotoxic, immunomodulatory and immunostimulatory potential of bromo- and cyano-substituted azulenes on the mammalian macrophages. These unique compounds had differential effects on the production of pro-inflammatory cytokines and they were anti-inflammatory immunomodulators. Furthermore, they exerted anti-proliferative effect on breast and prostate cancer cells which supports their anti-cancer potential as well.
dc.identifier.doi10.1007/s10753-020-01186-0
dc.identifier.endpage1018
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue3
dc.identifier.pmid31955292
dc.identifier.scopus2-s2.0-85078292719
dc.identifier.scopusqualityQ1
dc.identifier.startpage1009
dc.identifier.urihttps://doi.org/10.1007/s10753-020-01186-0
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2351
dc.identifier.volume43
dc.identifier.wosWOS:000539720400020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectazulene
dc.subjectmacrophages
dc.subjectprostate cancer
dc.subjectbreast cancer
dc.subjectinflammation
dc.titleAnti-Cancer and Anti-Inflammatory Activities of Bromo- and Cyano-Substituted Azulene Derivatives
dc.typeArticle

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