Photothermal and photodynamic responses of core-shell Mo2C@C@Fucoidan nanospheres

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dc.authoridTuncel, Ayca/0000-0003-0699-3309
dc.contributor.authorTuncel, Ayca
dc.contributor.authorSert, Buse
dc.contributor.authorOzel, Derya
dc.contributor.authorKaya, Gul
dc.contributor.authorHarputlu, Ersan
dc.contributor.authorUnlu, Cumhur Gokhan
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-03-17T12:27:02Z
dc.date.available2025-03-17T12:27:02Z
dc.date.issued2025
dc.departmentTarsus Üniversitesi
dc.description.abstractMo2C structure, a transition metal carbide, is known for its exceptional properties including high chemical and thermal stability and surface activity. Recently, carbon-modified Mo2C structures have found widespread applications due to their effectiveness. Here, we synthesized pomegranate-like Mo2C@C nanospheres and coated them with poly(allylamine hydrochloride) (PAH) and fucoidan structures. Characterization techniques including FE-SEM, HR-TEM, XRD, XPS, and zeta potential analysis were employed. We investigated the effect of Mo2C@C@Fuc nanospheres by quantitatively evaluating their photothermal conversion efficiency. Under irradiation at wavelengths of 808 nm and 1064 nm with a power intensity of 2 W/cm2, these nanospheres could convert up to 15 % of the incident laser energy into heat, outperforming conventional materials. Stability tests in various physiological pH environments confirmed their durability under NIR irradiation, ensuring operational integrity in biological environments. In addition, they showed significant efficiency in the production of singlet oxygen, making them promising agents for PDT. Biodegradation studies indicated safe degradation after ther- apeutic application, highlighting their environmental and physiological compatibility. Integrating Mo2C@C@- Fuc nanospheres into anticancer strategies combines the advantages of PTT and PDT, promising improved therapeutic outcomes with high biocompatibility.
dc.description.sponsorshipScientific and Technological Research Council of Turkey, TUBITAK [122Z055]
dc.description.sponsorshipThis research was funded by The Scientific and Technological Research Council of Turkey, TUBITAK (Grant Number: 122Z055) . The authors acknowledge the Ege University Institute of Nuclear Sciences and the Tarsus University Department of Engineering Fundamental Sciences for conducting the experimental work designed for the present study.
dc.identifier.doi10.1016/j.matchemphys.2024.130088
dc.identifier.issn0254-0584
dc.identifier.issn1879-3312
dc.identifier.scopus2-s2.0-85207796960
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.matchemphys.2024.130088
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2025
dc.identifier.volume329
dc.identifier.wosWOS:001349453000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofMaterials Chemistry and Physics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectMo2C@C nanosphere
dc.subjectFucoidan
dc.subjectMo2C@C@Fuc
dc.subjectPhotothermal conversation efficiency
dc.subjectROS generation
dc.titlePhotothermal and photodynamic responses of core-shell Mo2C@C@Fucoidan nanospheres
dc.typeArticle

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