Synthesis, Characterization, and Investigation of Corona Formation of Dipeptide-Based Nanomaterials

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dc.authoridShcharbin, Dzmitry/0000-0002-1414-4465
dc.authoridBOZDOGAN, BETUL/0000-0003-1546-3895
dc.authoridOdabasi, Mehmet/0000-0002-2589-9919
dc.authoridDIKICI, EMRAH/0000-0002-3086-8156
dc.contributor.authorDikici, Emrah
dc.contributor.authorAcet, Burcu Onal
dc.contributor.authorBozdogan, Betuel
dc.contributor.authorAcet, Omur
dc.contributor.authorHalets-Bui, Inessa
dc.contributor.authorShcharbin, Dzmitry
dc.contributor.authorOdabasi, Mehmet
dc.date.accessioned2025-03-17T12:25:14Z
dc.date.available2025-03-17T12:25:14Z
dc.date.issued2025
dc.departmentTarsus Üniversitesi
dc.description.abstractPeptide-based nanomaterials can be easily functionalized due to their functional groups, as well as being biocompatible, stable under physiological conditions, and nontoxic. Here, diphenylalanineamide-based nanomaterials (FFANMs) were synthesized, decorated with Ca2+ ions to set the surface charge, and characterized for possible use in gene delivery and drug release studies. FFANMs were characterized by SEM, TEM, dynamic light scattering (DLS), and LC-MS/MS. Corona formation and biocompatible studies were also carried out. Some of the data obtained are as follows: FFANMs have a diameter of approximately 87.93 nm. While the zeta potentials of FFANMs and Ca2+@FFANMs were -20.1 mV and +9.3 mV, respectively, after corona formation with HSA and IgG proteins, they were shifted to -7.6 mV and -3.7 mV, respectively. For gene delivery studies, zeta potentials of Ca2+@FFANMs and DNA interactions were also studied and found to shift to -9.7 mV. Cytotoxicity and biocompatibility studies of NMs were also studied on HeLa and HT29 cell lines, and decreases of about 5% and 10% in viability at the end of 24 h and 72 h incubation times were found. We think that the results obtained from this study will assist the groups working in the relevant field.
dc.description.sponsorshipScientific and Technological Research Council of Turkey; Belarussian Republican Foundation for Fundamental Research (BRFFR) [B21TUB-001]; Scientific and Technological Application and Research Center of Aksaray University; [220N178]
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (Grant Number: 220N178) and by the Belarussian Republican Foundation for Fundamental Research (BRFFR, grant number: B21TUB-001). The authors gratefully acknowledge the use of the services and facilities of the Scientific and Technological Application and Research Center of Aksaray University (ASUBTAM).
dc.identifier.doi10.3390/ma18010108
dc.identifier.issn1996-1944
dc.identifier.issue1
dc.identifier.pmid39795753
dc.identifier.scopus2-s2.0-85214449427
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/ma18010108
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1576
dc.identifier.volume18
dc.identifier.wosWOS:001393626700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectdiphenylalanineamide dipeptide
dc.subjectnanomaterials
dc.subjectprotein corona
dc.subjectself-assembly
dc.subjectbiocompatibility
dc.titleSynthesis, Characterization, and Investigation of Corona Formation of Dipeptide-Based Nanomaterials
dc.typeArticle

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