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    Antimicrobial photodynamic therapy against Staphylococcus Aureus using zinc phthalocyanine and zinc phthalocyanineintegrated TiO2 nanoparticles
    (World Scientific Publishing Co., 2020) Tunçel, Ayça; Öztürk, İsmail; Ince, Mine; Ocakoglu, Kasim; Hoşgör-Limoncu, Mine; Yurt, Fatma
    Antibiotic resistance is an increasing healthcare problem worldwide. In the present study, the effects of antimicrobial photodynamic therapy (APDT) of ZnPc and ZnPc-integrated TiO2 nanoparticles (ZnPc-TiO2) were investigated against Staphylococcus aureus. A light emitting diode (LED) (630-700 nm, 17.4 mW/cm2) was used on S. aureus at different light doses (8 J/cm2 for 11 min, 16 J/cm2 for 22 min, 24 J/cm2 for 33 min) in the presence of the compounds under the minimum inhibitory concentration values. Both compounds showed similar phototoxicity toward S. aureus when high light doses (16 and 24 J/cm2) were applied. In addition, the success of APDT increased with an increasing light dose. © 2021 by World Scientific Publishing Co. Pte. Ltd.