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    Anti-Inflammatory Effects of Coumarin-Selenophene Derivatives on LPS-Stimulated RAW 264.7 Macrophage Cells
    (Maik Nauka/Interperiodica/Springer, 2022) Yildirim, M.; Unal, Z. N.; Ersatir, M.; Yetkin, D.; Degirmenci, U.; Giray, E. S.
    Coumarin and coumarin derivatives have been known for their anti-viral, anti-oxidant, anti-cancer and anti-inflammatory activities. Changes in biological activity when these biologically active compounds are combined with different heterocyclic groups are among the topics of interest to researchers in recent years. Therefore, a series of coumarin-selenophene hybrid compounds have been synthesized. Products are fully characterized by NMR and FT-IR spectroscopic techniques. The prepared compounds are screened for their anti-inflammatory potencies on LPS induced mouse macrophage cell line (RAW 264.7). The results showed that coumarin-selenophene hybrid compounds were not cytotoxic at the tested concentrations on RAW 264.7 macrophages. Also, these compounds decreased TNF- alpha, IL-6 secretion, and NO, PGE(2) production in dose-depended manner. According to our results, coumarin-selenophene hybrid compounds have the capacity to moderate the immune response and a potential anti-inflammatory activity.
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    Öğe
    Coumarin Hybrids as Cholinesterase Inhibitors
    (Maik Nauka/Interperiodica/Springer, 2023) Yildirim, M.; Ersatir, M.; Yalin, S.; Giray, E. S.
    Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are two important enzymes involved in the breakdown of the neurotransmitter acetylcholine and other choline esters. Coumarins are biologically active compounds naturally found in the fruit, bark, stems, and leaves of many plants, including Tonka bean, acacia, lavender, deer tongue, apricot, strawberry, cherry, and cinnamon. Coumarin and coumarin hybrids have antitumor, antioxidant, antiviral, anticonvulsant, anti-inflammatory, antimicrobial, and antiproliferative activity. AChE and BuChE enzyme inhibition effects of 12 different coumarin derivatives (Ia-Ih) and (IIa-IId) synthesized and 16 coumarin-selenophene hybrid compounds (IVa-IVh) and (Va-Vh) were investigated. Compound (Vc) and (Vg) showed the most potent inhibitor activity against AChE.