Browsing by Author "Öztürk, İsmail"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Antimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots(Springer Link, 2023) Ceylan, Seda; Küçükosman, Rıdvan; Yurt, Fatma; Özel, Derya; Öztürk, İsmail; Demir, Didem; Ocakoğlu, KasımThe wound environment is a breeding ground for pathogens, and traditional wound dressing materials lack antibacterial properties. In this work, we aimed to develop PVA/chitosan (P/C)-based wound dressing scaffolds with anti-infective properties using Cu2ZnSnS4 quantum dots (CZTS QDs) to prevent infections in the wound. CZTS quantum dots were prepared by a simple hydrothermal process and characterized using appropriate techniques such as TEM, XRD, FTIR spectrum, and UV-Vis absorption spectroscopy. CZTS QDs were subsequently loaded at different concentrations onto PVA/chitosan membranes (0, 1.6, 2.5 and 3.3% w/w, based on the total polymer quantity). The chemical structure, contact angle and mechanical properties of the membranes were analyzed, and their antimicrobial activities and cell viability were also investigated. The cytocompatibility of the membranes and cell morphology was investigated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM. Based on studies on the interactions between membranes and cells, it was determined that incorporation of CZTS QDs into the membrane did not cause toxicity. To the best of our knowledge, this is the first report on loading CZTS QDs into membranes for tissue engineering applications, and the overall findings suggest that CZTS QDs-integrated membranes might have potentially appealing uses as antimicrobial films for wound healing.Item Antimicrobial photodynamic therapy against Staphylococcus Aureus using zinc phthalocyanine and zinc phthalocyanineintegrated TiO2 nanoparticles(World Scientific Publishing Co., 2020) Tunçel, Ayça; Öztürk, İsmail; Ince, Mine; Ocakoglu, Kasim; Hoşgör-Limoncu, Mine; Yurt, FatmaAntibiotic resistance is an increasing healthcare problem worldwide. In the present study, the effects of antimicrobial photodynamic therapy (APDT) of ZnPc and ZnPc-integrated TiO2 nanoparticles (ZnPc-TiO2) were investigated against Staphylococcus aureus. A light emitting diode (LED) (630-700 nm, 17.4 mW/cm2) was used on S. aureus at different light doses (8 J/cm2 for 11 min, 16 J/cm2 for 22 min, 24 J/cm2 for 33 min) in the presence of the compounds under the minimum inhibitory concentration values. Both compounds showed similar phototoxicity toward S. aureus when high light doses (16 and 24 J/cm2) were applied. In addition, the success of APDT increased with an increasing light dose. © 2021 by World Scientific Publishing Co. Pte. Ltd.
