Ayaz, FurkanUgur, NazOcakoglu, KasimInce, Mine2025-03-172025-03-1720191572-10001873-1597https://doi.org/10.1016/j.pdpdt.2019.02.002https://hdl.handle.net/20.500.13099/1994In this study, a series of subphthalocyanines (SubPcs) derivatives were synthesized to generate unique immunomodulatory molecules that can be activated through photo-induction. Immunomodulatory agents have a great potential in medicine to manipulate the immune system according to our needs and prevent disease symptoms. Inflammation is one of these symptoms and macrophages play a crucial role in the generation of inflammatory responses. Being able to control the activity of these agents through photo-induction enables the fine tuning on their activities in a location specific and non-invasive manner with possibly minor side effects. Mammalian macrophages' pro-inflammatory activity was examined in the presence of our compounds as well as LPS as a danger mimic. These compounds exerted photo-induced anti-inflammatory activities on the macrophages. Number of Cl atoms was a defining factor in their photo-induced anti-inflammatory immunomodulatory efficiencies.eninfo:eu-repo/semantics/closedAccessInflammationmacrophagesimmunomodulatory agentssuphthalocyaninesanti-inflammatory agentsPhotodynamic therapyArticle10.1016/j.pdpdt.2019.02.00225499503Q2WOS:0004650596000762-s2.0-8506164020330738845Q1