Ugur, NazHarputlu, ErsanSezer, Canan VejselovaDemirdogen, Ruken EsraInce, MineUnlu, C. GokhanYurt, Fatma2025-03-172025-03-1720221773-22472588-8943https://doi.org/10.1016/j.jddst.2021.102778https://hdl.handle.net/20.500.13099/2062The uniformly dispersed hollow mesoporous carbon nanoparticles (HMCNPs) were successfully synthesized by hard-template methods, and D-NMAPPD (B13) was successfully loaded onto the nanoparticle surface for the first time. Structural properties of bare and B13 loaded HMCNPs (HMCNs-B-13) were investigated by Fourier Transform Infrared Spectroscopy (FT-IR), Field Emission-Scanning Electron Microscopy (FE-SEM), Thermal Gravimetric Analysis (TG). The amount of drug released was determined via in vitro drug release studies at 37 degrees C in SBF through UV-Vis spectrometric and thermal analyses. TG data revealed that the proportion of loaded B-13 was 33.60%. Their ability to induce apoptosis in cultures of A549 human lung adenocarcinoma cells was investigated, and the inhibitory effect of HMCNPs-B-13 on lung cancer cell proliferation was determined in vitro. The IC50 values determined after application periods of 24 and 48 h were found to be 16.13 mu g/mL and 12.96 mu g/mL, respectively. The role of HMCNPs-B-13 on the morphology and ultrastructure of A549 cells was also investigated by confocal microscopy and Transmission electron microscopy (TEM) studies.eninfo:eu-repo/semantics/closedAccessHollow mesoporous carbon nanoparticlesD-NMAPPDLung cancerCytotoxicityArticle10.1016/j.jddst.2021.10277867Q1WOS:0007880846000022-s2.0-85121591601Q1