Kaya, GülKoç, Eda OndulÖzdemir, SadinYalçın, M. SerkanOcakoğlu, KasımDizge, Nadir2024-05-072024-05-072024Kaya, G., Koc, E.O., Özdemir, S. Yalçın, M. S.,Ocakoğlu, K. ve Dizge, N. (2024). The Syntheses of Chromium Aluminum Carbide (Cr2AlC) MAX Phase and Cr2CTx MXene and Investigation of Their Antimicrobial Properties. Appl Biochem Biotechnol . https://doi.org/10.1007/s12010-024-04910-w02732289https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188820827&doi=10.1007%2fs12010-024-04910-w&partnerID=40&md5=cf7349e5c41cf81f0611acdf524a783dhttps://hdl.handle.net/20.500.13099/225Chromium aluminum carbide (Cr2AlC) MAX phase and Cr2CTx (MXene-Cr) were synthesized by the pressureless sintering method and hydrothermal method, respectively. In addition to this, the free radical scavenging activities (FRSA) of MAX-Cr phase and MXene-Cr compounds were tested and compared with ascorbic acid and trolox as standard compounds. The obtained FRSA results of MAX-Cr phase and MXene-Cr were 42.82 and 59.64%, respectively, at 100 mg/L concentration. MXene-Cr showed a 66.90% inhibitory effect on α-amylase at 200 mg/L. The DNA nuclease activity of compounds was determined to be extremely satisfactory at 50, 100, and 200 mg/L concentrations. Moreover, the prepared MAX-Cr phase and MXene-Cr were investigated for antimicrobial activity against six bacterial and two fungal strains by the broth microdilution method. Compounds provided more significant inhibition against Gram-positive bacteria than Gram-negative bacteria and fungi. MAX-Cr phase and MXene-Cr almost completely inhibited microbial cell viability at a 25 mg/L concentration. Additionally, MXene-Cr showed 89.86% and 87.01% antibiofilm activity against S. aureus and P. aeruginosa, respectively, while the antibiofilm activity of the MAX-Cr phase was over 90%.enginfo:eu-repo/semantics/restrictedAccessAntimicrobialAntioxidantBiofilm inhibitionCr2AlC MAX phase (MAX-Cr)Cr2CTx (MXene-Cr)DNA cleavageAluminum compoundsAscorbic acidBacteriaCarbidesChromium compoundsFree radicalsAnti-microbial propertiesAntibiofilmsAntimicrobialBiofilm inhibitionsCr2AlC MAX phase (MAX-cr)Cr2CTx (mxene-cr)DNA cleavageFree radical-scavenging activitiesMAX-phaseSynthesisedSinteringarticle10.1007/s12010-024-04910-wQ2WOS:0011947634000022-s2.0-8518882082738538871