Bouali, WiemErk, NevinSert, BuseHarputlu, Ersan2024-08-282024-08-282024Bouali, W., Erk, N., Sert, B. ve Harputlu, E. (2024). Evaluating the simultaneous electrochemical determination of antineoplastic drugs using LaNiO3/g-C3N4@RGH nanocomposite material, Talanta, 278. Erişim adresi: https://doi.org/10.1016/j.talanta.2024.1264860039-91401873-3573https://doi.org/10.1016/j.talanta.2024.126486https://hdl.handle.net/20.500.13099/375A novel electrochemical sensor based on LaNiO3/g-C3N4@RGH nanocomposite material was developed to simultaneously determine Ribociclib (RIBO) and Alpelisib (ALPE). Ribociclib and Alpelisib are vital anticancer medications used in the treatment of advanced breast cancer. The sensor exhibited excellent electrocatalytic activity towards the oxidation of RIBO and ALPE, enabling their simultaneous detection. The fabricated sensor was characterized using various techniques, including energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS), which confirmed the successful synthesis of the LaNiO3/g-C3N4@RGH composite material. Electrochemical characterization revealed enhanced conductivity and lower resistance of the modified electrode compared to the bare electrode. The developed sensor exhibited high repeatability, reproducibility, stability, and selectivity toward RIBO detection. Furthermore, the sensor displayed high sensitivity with low detection limits of 0.88 nM for RIBO and 6.1 nM for ALPE, and linear ranges of 0.05–6.2 μM and 0.5–6.5 μM, respectively. The proposed electrochemical sensor offers a promising approach for simultaneously determining RIBO and ALPE in pharmaceutical formulations and biological samples with recovery data of 98.7–102.0 %, providing a valuable tool for anticancer drug analysis and clinical research.enginfo:eu-repo/semantics/closedAccessAlpelisibElectrochemical sensorNanocomposite materialPharmaceutical productsRibociclibarticle10.1016/j.talanta.2024.126486278113Q10012842026000012-s2.0-85197524537