Bouali, WiemGenc, Asena AyseErk, NevinKaya, GulSert, BuseOcakoğlu, Kasım2024-05-072024-05-072024Bouali, W., Genc, A.A., Erk, N., Kaya, G., Sert, B ve Ocakoğlu, K.(2024). Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples. Microchim Acta 191, 135. https://doi.org/10.1007/s00604-024-06207-5https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185108194&doi=10.1007%2fs00604-024-06207-5&partnerID=40&md5=b2876a58ef2f8a6742bb76166d8a8f2dhttps://hdl.handle.net/20.500.13099/226A highly sensitive electrochemical sensor is reported that employs a modified electrode for the precise measurement of cabotegravir, a potent anti-HIV drug. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were utilized for this purpose. Electrode modification involved the immobilization of Cr2AlC MAX phase/g-C3N4 onto a glassy carbon electrode (GCE) to enhance its electrocatalytic activity and selectivity for cabotegravir detection. Under the optimal experimental conditions, the working potential (vs. Ag/AgCl) was to 0.93 V. The developed sensor exhibited a good linear relationship in the range 0.05 µM to 9.34 µM with a low limit of detection of 4.33 nM, signifying its exceptional sensitivity. Additionally, it demonstrated successful cabotegravir detection in pharmaceutical formulations and biological samples, achieving an RSD below 3.0%. The recoveries fell within the range 97.7 to 102%, confirming the sensor's potential for real-sample applications. This innovative electrochemical sensor represents a significant advancement, providing a simple, reliable, and sensitive tool for the accurate measurement of cabotegravir. Its potential applications include optimizing drug dosages, monitoring treatment responses, and supporting the development of cabotegravir-based pharmaceutical products, thereby contributing to advancements in HIV therapy and prevention strategies.enginfo:eu-repo/semantics/restrictedAccessCabotegravirCr2AlC MAX phaseDifferential pulse voltammetryElectrochemical sensorg-C3N4Modified glassy carbon electrodePharmaceutical productsCarbonDiketopiperazinesElectrochemical TechniquesLimit of DetectionPharmaceutical PreparationsPyridonesAluminum compoundsCyclic voltammetryDrug dosageDrug productsElectrochemical impedance spectroscopyGlassGlass membrane electrodescabotegravirBiological samplesMAX-phaseModified electrodesModified glassy carbon electrodePharmaceutical productsarticle10.1007/s00604-024-06207-51913Q12-s2.0-8518510819438355771