Yildirim, MetinAcet, Omur2025-03-172025-03-1720232666-5239https://doi.org/10.1016/j.apsadv.2023.100527https://hdl.handle.net/20.500.13099/2261This study aims to formulate naringenin (Nar)-loaded pH/temperature sensitive nanopolymers for therapeutic options for inflammatory diseases. For this aim, Nar loaded SNPs (NarSNPs) were synthesized by miniememulsion method and Scanning electron microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR) and, Dynamic Light Scattering (DLS) characterization experiments were conducted. The cytokines release (IL-6 and TNF-alpha) and cell viability were determined on lipopolysaccharide (LPS) induced RAW 264.7 macrophages. SNPs were determined as a potential naringenin carrier in terms of loading capacity, entrapment efficiency, pH/ temperature dependent release, and preservation of bioactivity of Nar. According to our cell viability analyses, NarSNPs are safe at concentration 120 mu g/mL. pH/temperature sensitive SNPs decreased the levels of the proinflammatory cytokines IL-6, TNF-alpha 3.95 and 4.35 times more efficiently than free Nar, respectively. These results indicate that SNPs increase bioactivity of Nar against adverse effects of inflammatory response.eninfo:eu-repo/semantics/openAccessNaringeninSmart nanopolymersTemperature sensitive polymerpH sensitive polymerRaw 264.7 cellsArticle10.1016/j.apsadv.2023.10052718N/AWOS:0011287475000012-s2.0-85179114687Q1