Sanap, DnyaneshwarAvhad, LataAhire, SatishMirzaei, MahmoudKumar, DeepakGhotekar, SureshGaikwad, Nitin D.2025-03-172025-03-1720240922-61681568-5675https://doi.org/10.1007/s11164-024-05322-5https://hdl.handle.net/20.500.13099/2326Spinel copper ferrite magnetic nanoparticles (CuFe2O4 MNPs) are one of the prominent spinel ferrites due to their magnetic properties. As a result of the current investigation, the magnetic spinel copper ferrite nanoparticles (CuFe2O4 MNPs) were successfully fabricated via a green synthesis approach using freshly prepared Yogurt of cow milk as a capping agent by sol-gel auto-combustion route and its catalytic effect towards synthesizing ethyl 1,2,3,4-tetrahydro-2-oxo-4-aryl pyrimidine-5-carboxylate (DHPMs) scaffold was explored. Further, the phase formation, crystallinity, particle size, grain morphology, and the property of magnetism of bio-fabricated spinel CuFe2O4 NPs were explored by XRD, FESEM, EDX, FTIR, UVDRS, and VSM analysis. Furthermore, one-pot synthesis of DHPMs scaffold via multicomponent (MCR) Biginelli reaction was examined using biosynthesized spinel CuFe2O4 magnetic heterogeneous catalyst (C1 and C2 nanocrystalline phase). To achieve the high yields (90-98%) of DHPMs scaffold synthesis with an extensive range of aromatic carbaldehyde using minimum loading of heterogeneous catalysts within minimum reaction time and easy catalyst recovery by a peripheral magnet were examined. Therefore, this protocol presents an extensive scope for Biginelli reaction using magnetically separable heterogeneous catalyst synthesis via a green approach.eninfo:eu-repo/semantics/closedAccessGreen synthesisCuFe2O4 NPsHeterogeneous nanocatalysisMagnetically retrievable catalystArticle10.1007/s11164-024-05322-550836873711Q2WOS:0012484457000022-s2.0-85196042627Q2