Yildirim, M.Unal, Z. N.Ersatir, M.Yetkin, D.Degirmenci, U.Giray, E. S.2025-03-172025-03-1720221068-16201608-330Xhttps://doi.org/10.1134/S1068162022060279https://hdl.handle.net/20.500.13099/1769Coumarin and coumarin derivatives have been known for their anti-viral, anti-oxidant, anti-cancer and anti-inflammatory activities. Changes in biological activity when these biologically active compounds are combined with different heterocyclic groups are among the topics of interest to researchers in recent years. Therefore, a series of coumarin-selenophene hybrid compounds have been synthesized. Products are fully characterized by NMR and FT-IR spectroscopic techniques. The prepared compounds are screened for their anti-inflammatory potencies on LPS induced mouse macrophage cell line (RAW 264.7). The results showed that coumarin-selenophene hybrid compounds were not cytotoxic at the tested concentrations on RAW 264.7 macrophages. Also, these compounds decreased TNF- alpha, IL-6 secretion, and NO, PGE(2) production in dose-depended manner. According to our results, coumarin-selenophene hybrid compounds have the capacity to moderate the immune response and a potential anti-inflammatory activity.eninfo:eu-repo/semantics/closedAccesscoumarinselenopheneinflammationmacrophagesynthesisArticle10.1134/S106816202206027948612091214Q4WOS:0008706550000042-s2.0-85140253253Q4