Yildirim, M.Ersatir, M.Yalin, S.Giray, E. S.2025-03-172025-03-1720231068-16201608-330Xhttps://doi.org/10.1134/S1068162023050035https://hdl.handle.net/20.500.13099/1767Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are two important enzymes involved in the breakdown of the neurotransmitter acetylcholine and other choline esters. Coumarins are biologically active compounds naturally found in the fruit, bark, stems, and leaves of many plants, including Tonka bean, acacia, lavender, deer tongue, apricot, strawberry, cherry, and cinnamon. Coumarin and coumarin hybrids have antitumor, antioxidant, antiviral, anticonvulsant, anti-inflammatory, antimicrobial, and antiproliferative activity. AChE and BuChE enzyme inhibition effects of 12 different coumarin derivatives (Ia-Ih) and (IIa-IId) synthesized and 16 coumarin-selenophene hybrid compounds (IVa-IVh) and (Va-Vh) were investigated. Compound (Vc) and (Vg) showed the most potent inhibitor activity against AChE.eninfo:eu-repo/semantics/closedAccessAChEBuChEcoumarincoumarin-selenophenealzheimer's diseaseArticle10.1134/S1068162023050035495970975Q4WOS:0010529559000032-s2.0-85168662058Q4