Yurt, FatmaOcakoglu, KasimEr, OzgeSoylu, Hale MelisInce, MineAvci, Cigir BirayKurt, Cansu Caliskan2025-03-172025-03-1720191088-42461099-1409https://doi.org/10.1142/S1088424619500639https://hdl.handle.net/20.500.13099/1755This study, subphthalocyanines (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc-TiO2) were synthesized as novel photosensitizers. Their PDT effects were evaluated. Furthermore, nuclear imaging potential of I-131-labelled SubPc/SubPc-TiO2 were examined in mouse mammary carcinoma (EMT6) and cervix adenocarcinoma (HeLa) cell lines. The uptake results show that SubPc labelled with I-131 radionuclide ((131) I-SubPc) in EMT6 and HeLa cell lines was found to be approximately the same as in the WI38 cell line. However, the uptake values of SubPc-TiO2 labelled with I-131(I-131-SubPc- TiO2) in EMT6 and HeLa cell lines were determined to be two times higher than in the WI38 cell line. In other words, the target/non-target tissue ratio was identified as two in the EMT6 and HeLa cell lines. I-131-SubPc-TiO2 is promising for imaging or treatment of breast and cervix tumors. In vitro photodynamic therapy studies have shown that SubPc and SubPc-TiO2 are suitable agents for PDT. In addition, SubPc-TiO2 has higher phototoxicity than SubPc. As a future study, in vivo experiments will be held and performed in tumor-bearing nude mice.eninfo:eu-repo/semantics/closedAccesssubphthalocyaninephotodynamic therapynuclear imagingtitanium nanoparticleArticle10.1142/S1088424619500639237-8908915Q4WOS:0004841158000182-s2.0-85109635006Q3