Investigation of in vitro biological activities of hollow mesoporous carbon nanoparticles bearing D-NMAPPD on human lung adenocarcinoma cells

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dc.authoridEmen, Fatih Mehmet/0000-0002-4974-2940
dc.authoridUnlu, Cumhur Gokhan/0000-0003-2554-5886
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridOcakoglu, Kasim/0000-0003-2807-0425
dc.contributor.authorUgur, Naz
dc.contributor.authorHarputlu, Ersan
dc.contributor.authorSezer, Canan Vejselova
dc.contributor.authorDemirdogen, Ruken Esra
dc.contributor.authorInce, Mine
dc.contributor.authorUnlu, C. Gokhan
dc.contributor.authorYurt, Fatma
dc.date.accessioned2025-03-17T12:27:05Z
dc.date.available2025-03-17T12:27:05Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractThe uniformly dispersed hollow mesoporous carbon nanoparticles (HMCNPs) were successfully synthesized by hard-template methods, and D-NMAPPD (B13) was successfully loaded onto the nanoparticle surface for the first time. Structural properties of bare and B13 loaded HMCNPs (HMCNs-B-13) were investigated by Fourier Transform Infrared Spectroscopy (FT-IR), Field Emission-Scanning Electron Microscopy (FE-SEM), Thermal Gravimetric Analysis (TG). The amount of drug released was determined via in vitro drug release studies at 37 degrees C in SBF through UV-Vis spectrometric and thermal analyses. TG data revealed that the proportion of loaded B-13 was 33.60%. Their ability to induce apoptosis in cultures of A549 human lung adenocarcinoma cells was investigated, and the inhibitory effect of HMCNPs-B-13 on lung cancer cell proliferation was determined in vitro. The IC50 values determined after application periods of 24 and 48 h were found to be 16.13 mu g/mL and 12.96 mu g/mL, respectively. The role of HMCNPs-B-13 on the morphology and ultrastructure of A549 cells was also investigated by confocal microscopy and Transmission electron microscopy (TEM) studies.
dc.identifier.doi10.1016/j.jddst.2021.102778
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85121591601
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2021.102778
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2062
dc.identifier.volume67
dc.identifier.wosWOS:000788084600002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectHollow mesoporous carbon nanoparticles
dc.subjectD-NMAPPD
dc.subjectLung cancer
dc.subjectCytotoxicity
dc.titleInvestigation of in vitro biological activities of hollow mesoporous carbon nanoparticles bearing D-NMAPPD on human lung adenocarcinoma cells
dc.typeArticle

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