Tamoxifen Delivery to Breast Cancer Cells (MCF-7) Via Hydroxyapatite Microspheres

Basit Öğe Kaydı
dc.contributor.authorKırbıyık, Binnaz
dc.contributor.authorMazmancı, Birgül
dc.contributor.authorYarlılar, Şeyma Gülnaz
dc.contributor.authorUğur, Naz
dc.contributor.authorOcakoğlu, Kasım
dc.date.accessioned2025-03-16T12:43:12Z
dc.date.available2025-03-16T12:43:12Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description2017-1-TP2-2232
dc.description.abstractDrug delivery systems have been used in cancer treatment to increase drug effectiveness. The hydroxyapatite (HAP) based materials used in this area can provide drug transport to the target site without its deterioration. In this study, porous hollow hydroxyapatite microspheres (PHHMs) were produced by using the hydrothermal method. Tamoxifen (TAM) used in the treatment of breast cancer has been covalently attached to the produced microspheres. The obtained microsphere structures (tamoxifen-loaded hydroxyapatite, TAM/H) were successfully characterized by ATR-FTIR, FE-SEM, XRD, and DLS methods. The breast cancer cell line MCF-7 was used to examine the effect of the hybrid structure. The cytotoxic and genotoxic effects of TAM/H was compared with the TAM groups on MCF-7. Our results have showed that, the decrease in cell viability at 24 and 36 hours were still continued at 48 hours only in TAM/H groups. In addition, TAM/H was found to show a genotoxic affect by the increment in genetic damage index (GDI) and damaged cell percentage (DCP%). As a result, use of hydroxyapatite was suitable for the transport of TAM and that covalent binding was suitable for drug particle interaction with hybrid structure and thus controlled drug release occurred.
dc.description.sponsorshipMersin Üniversitesi
dc.identifier.doi10.46239/ejbcs.1040161
dc.identifier.endpage118
dc.identifier.issn2651-5237
dc.identifier.issue(Ek sayı 1)
dc.identifier.startpage111
dc.identifier.urihttps://doi.org/10.46239/ejbcs.1040161
dc.identifier.urihttps://hdl.handle.net/20.500.13099/602
dc.identifier.volume5
dc.language.isoen
dc.publisherMuhammet DOĞAN
dc.relation.ispartofEurasian Journal of Biological and Chemical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250316
dc.subjectHydroxyapatite microsphere
dc.subjectTamoxifen
dc.subjectHydrothermal method
dc.subjectMCF-7
dc.subjectCytotoxicity
dc.subjectGenotoxicity
dc.titleTamoxifen Delivery to Breast Cancer Cells (MCF-7) Via Hydroxyapatite Microspheres
dc.typeArticle

Dosyalar

Koleksiyon

Öksüz Yayınlar