Antibacterial properties of subphthalocyanine and subphthalocyanine-TiO2 nanoparticles on Staphylococcus aureus and Escherichia coli

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dc.authoridOZTURK, ISMAIL/0000-0002-2669-3090
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridTuncel, Ayca/0000-0003-0699-3309
dc.authoridInce, Mine/0000-0002-9164-0446
dc.contributor.authorOzturk, Ismail
dc.contributor.authorTuncel, Ayga
dc.contributor.authorInce, Mine
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorHosgor-Limoncu, Mine
dc.contributor.authorYurt, Fatma
dc.date.accessioned2025-03-17T12:25:34Z
dc.date.available2025-03-17T12:25:34Z
dc.date.issued2018
dc.departmentTarsus Üniversitesi
dc.description.abstractNowadays the problem of antimicrobial resistance is the most important cause of morbidity and mortality in the treatment of infectious diseases worldwide. Treatment options for antimicrobial-resistant microorganisms are quite limited. Therefore, alternative treatment strategies are needed to control infectious diseases. Antimicrobial photodynamic therapy (aPDT) is one of the new treatment modalities proposed for a wide variety of infections. In the basic principle of aPDT, photosensitizers (PS) produce free radicals by irradiating them with harmless light at the appropriate wavelength, and this causes microorganism cell cytotoxicity. In this study, light emitting diodes (LED) (630-700 nm, 17.4 mW/cm(2)) were used on Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) at different light doses under the minimum inhibitory concentration (MIC) values of SubPc and SubPc-integrated TiO2 nanoparticles (SubPc-TiO2) concentration. Both compounds show good phototoxicity toward S. aureus when high light doses (16, 24 J/cm(2)) were applied. In addition, SubPc-TiO2 were found to be more effective than SubPc in aPDT of S. aureus. In E. coli, the success of aPDT has been shown to be dependent on the increased light dose (20, 30 J/cm(2) ) for both compounds. As a result, the aPDT activity of SubPc-TiO2 is more effective than SubPc in increasing light doses.
dc.description.sponsorshipEge University Scientific Research Projects (BAP) commission [18 NBE 003]
dc.description.sponsorshipThis work was supported by the Ege University Scientific Research Projects (BAP) commission with 18 NBE 003 project code.
dc.identifier.doi10.1142/S1088424618501122
dc.identifier.endpage1105
dc.identifier.issn1088-4246
dc.identifier.issn1099-1409
dc.identifier.issue12
dc.identifier.scopus2-s2.0-85057355553
dc.identifier.scopusqualityQ3
dc.identifier.startpage1099
dc.identifier.urihttps://doi.org/10.1142/S1088424618501122
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1758
dc.identifier.volume22
dc.identifier.wosWOS:000453779800008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWorld Scientific Publ Co Pte Ltd
dc.relation.ispartofJournal of Porphyrins and Phthalocyanines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectantimicrobial photodynamic therapy
dc.subjectsubphthalocyanine
dc.subjectTiO2 nanoparticles
dc.subjectStaphylococcus aureus
dc.subjectEscherichia coli
dc.titleAntibacterial properties of subphthalocyanine and subphthalocyanine-TiO2 nanoparticles on Staphylococcus aureus and Escherichia coli
dc.typeArticle

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