Synthesis of axially disubstituted silicon phthalocyanines and investigation of their in vitro cytotoxic/phototoxic anticancer activities

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dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridTuncel, Ayca/0000-0003-0699-3309
dc.authoridOZEL, Derya/0000-0003-0596-5293
dc.contributor.authorYurt, Fatma
dc.contributor.authorSaka, Ece Tugba
dc.contributor.authorBiyiklioglu, Zekeriya
dc.contributor.authorTuncel, Ayca
dc.contributor.authorOzel, Derya
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-03-17T12:25:34Z
dc.date.available2025-03-17T12:25:34Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstractIn this study, two SiPcs have been selected and the photodynamic therapy potentials were evaluated of the Pcs. Synthesis of Axially 2-decyn-1-oxy disubstituted Es-SiPc-2 was newly synthesized by the reaction of SiPcCl2 with 2-decyn-1-ol in the presence of NaH in toluene. Furthermore, their nuclear imaging potentials were evaluated in human colon adenocarcinoma (HT-29) and human lung fibroblast cell (WI-38) cell lines. The uptake results have indicated that Es-SiPc labeled with I-131 radionuclide (I-131-Es-SiPc) was approximately 2-fold higher in the HT-29 cell line than the WI-38 cell line. In other words, the target/non-target tissue ratio is defined as two in the HT-29/WI-38 cell lines. Besides, the uptake values of I-131-Es-SiPc were found to be higher than I-131-Es-SiPc-2. I-131-Es-SiPc and I-131-Es-SiPc-2 are promising for imaging or treating colon adenocarcinoma. In vitrophotodynamic therapy (PDT) studies have shown that both compounds are suitable and can be used in this field. Also, Es-SiPc has been shown to have higher phototoxicity than Es-SiPc-2.
dc.identifier.doi10.1142/S1088424620500455
dc.identifier.endpage18
dc.identifier.issn1088-4246
dc.identifier.issn1099-1409
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85093503758
dc.identifier.scopusqualityQ3
dc.identifier.startpage10
dc.identifier.urihttps://doi.org/10.1142/S1088424620500455
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1754
dc.identifier.volume25
dc.identifier.wosWOS:000603050000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWorld Sci Publ Co Inc
dc.relation.ispartofJournal of Porphyrins and Phthalocyanines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectsilicon phthalocyanine
dc.subjectphotodynamic therapy
dc.subjectcolon adenocarcinoma
dc.subjectI-131
dc.titleSynthesis of axially disubstituted silicon phthalocyanines and investigation of their in vitro cytotoxic/phototoxic anticancer activities
dc.typeArticle

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