A magnetically recyclable yolk-shell Au nanocatalyst for catalytic reduction of nitroaromatics and investigation of cytotoxicity on healthy and cancerous cell lines
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Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study aimed to extract gold from waste water produced during secondary gold extraction and create a yolkshell catalyst with a magnetic nanoparticle core. Cytotoxicity tests were performed on healthy and cancerous cells to evaluate the potential of these gold nanoparticles, made from waste gold, in drug delivery. TEM and SEM results showed that the gold nanoparticles were uniformly dispersed in the silica shell of the catalyst without agglomeration. Cytotoxicity tests on healthy human bronchial epithelial cells (BEAS-2B) and cancer cells (SHSY5Y and A549) were conducted to assess the viability and potential use of these nanoparticles in medical drug delivery. Nanoparticles were used at concentrations ranging from 1 to 1000 mu g/mL, and the effects were studied at both 24 and 48 hour exposures. It was found that nanoparticles were nontoxic at low concentrations (<50 g/ mL) but their toxicity increased depending on time and concentration. It has been observed that the cytotoxic effect is less, especially in healthy cells. It was also found that nanoparticles from wastewater were less toxic. Moreover, cytotoxicity studies revealed a direct correlation between the increasing concentration of magnetic gold nanoparticles (MNP-3APP-Au from pure gold, MNP-3APW-Au from waste gold) and their cytotoxic effects. In addition, catalytic reduction of the environmentally toxic 4-nitrophenol, one of the application areas of gold, in the presence of sodium boron hydride was also carried out in order to evaluate the other possible applications of waste gold. It can be said that the catalytic activities of MNP-3APP-Au nanoparticles (98.09 % at 90 min.) obtained from pure gold salt are slightly better than MNP-3APW-Au nanoparticles (97.5 % at 35 min). However, although it takes longer to complete the para nitrophenol conversion, it can be said that the activity of MNP3APW-Au nanoparticles is quite high compared to the literature data.
Açıklama
Anahtar Kelimeler
Gold recovery, Drug targeting, Yolk shell nano-catalyst, Cytotoxicity, Au nanoparticles
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
1333
