Antimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots

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dc.authoridhttps://orcid.org/0000-0003-2807-0425
dc.authoridhttps://orcid.org/0000-0001-7432-7725
dc.authoridhttps://orcid.org/0000-0002-2977-2077
dc.authorscopusid55820407700
dc.authorscopusid36088420200
dc.authorscopusid57218339719
dc.authorwosidAAM-8078-2020
dc.authorwosidIYS-7709-2023
dc.authorwosidIVV-2642-2023
dc.contributor.authorCeylan, Seda
dc.contributor.authorKüçükosman, Rıdvan
dc.contributor.authorYurt, Fatma
dc.contributor.authorÖzel, Derya
dc.contributor.authorÖztürk, İsmail
dc.contributor.authorDemir, Didem
dc.contributor.authorOcakoğlu, Kasım
dc.date.accessioned2024-08-19T11:48:33Z
dc.date.available2024-08-19T11:48:33Z
dc.date.issued2023
dc.departmentFakülteler, Mühendislik Fakültesi, Mühendislik Temel Bilimleri Bölümü
dc.description.abstractThe wound environment is a breeding ground for pathogens, and traditional wound dressing materials lack antibacterial properties. In this work, we aimed to develop PVA/chitosan (P/C)-based wound dressing scaffolds with anti-infective properties using Cu2ZnSnS4 quantum dots (CZTS QDs) to prevent infections in the wound. CZTS quantum dots were prepared by a simple hydrothermal process and characterized using appropriate techniques such as TEM, XRD, FTIR spectrum, and UV-Vis absorption spectroscopy. CZTS QDs were subsequently loaded at different concentrations onto PVA/chitosan membranes (0, 1.6, 2.5 and 3.3% w/w, based on the total polymer quantity). The chemical structure, contact angle and mechanical properties of the membranes were analyzed, and their antimicrobial activities and cell viability were also investigated. The cytocompatibility of the membranes and cell morphology was investigated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM. Based on studies on the interactions between membranes and cells, it was determined that incorporation of CZTS QDs into the membrane did not cause toxicity. To the best of our knowledge, this is the first report on loading CZTS QDs into membranes for tissue engineering applications, and the overall findings suggest that CZTS QDs-integrated membranes might have potentially appealing uses as antimicrobial films for wound healing.
dc.identifier.citationCeylan, S., Küçükosman, R., Yurt, F., Özel, D., Öztürk, İ. Demir, D. ve Ocakoğlu, K. (2023). Antimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots. Polymer Bulletin, 80 (10), 11273–11293. Erişim adresi:https://doi.org/10.1007/s00289-022-04615-2
dc.identifier.doi10.1007/s00289-022-04615-2
dc.identifier.endpage11293en_US
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85142938628
dc.identifier.scopusqualityQ1
dc.identifier.startpage11273en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-022-04615-2
dc.identifier.urihttps://hdl.handle.net/20.500.13099/360
dc.identifier.volume80en_US
dc.identifier.wosWOS:000892917600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorOcakoğlu, Kasım
dc.institutionauthorKüçükosman, Rıdvan
dc.institutionauthorDemir, Didem
dc.language.isoen
dc.publisherSpringer Link
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCu2ZnSnS4 quantum dots
dc.subjectCZTS
dc.subjectChitosan
dc.subjectPVA
dc.subjectAbsorption spectroscopy
dc.subjectBiomechanics
dc.subjectChemical analysis
dc.subjectContact angle
dc.subjectCopper compounds
dc.subjectFourier transform infrared spectroscopy
dc.subjectMembranes
dc.subjectNanocrystals
dc.subjectTin compounds
dc.subjectZinc compounds
dc.subjectActivity enhancement
dc.subjectAnti-microbial activity
dc.subjectAntibacterial properties
dc.subjectBreeding grounds
dc.subjectChitosan film
dc.subjectCu2ZnSnS4 quantum dot
dc.subjectWound dressing materials
dc.subjectWound dressings
dc.titleAntimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots
dc.typeArticle

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