Anti-cancer activity of naringenin loaded smart polymeric nanoparticles in breast cancer

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dc.authoridAcet, Omur/0000-0003-1864-5694
dc.authoridkarakoc, veyis/0000-0002-2511-6478
dc.authoridODABASI, Mehmet/0000-0002-3288-132X
dc.contributor.authorYildirim, Metin
dc.contributor.authorAcet, Omur
dc.contributor.authorYetkin, Derya
dc.contributor.authorAcet, Burcu Onal
dc.contributor.authorKarakoc, Veyis
dc.contributor.authorOdabasi, Mehmet
dc.date.accessioned2025-03-17T12:27:05Z
dc.date.available2025-03-17T12:27:05Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractBreast cancer is the most common form of cancer among women worldwide, and approximately comprise 25% of all female malignancies. Naringenin (Nar) is a promising anticancer agent for breast cancer. However, its use as a therapeutic agent is limited due to its poor water solubility and bioavailability. The purpose of the present study is to prepare pH and thermo sensitive smart polymeric nanoparticles carrying naringenin (NarSPNPs) to improve bioavailability, and increase therapeutic efficacy against breast cancer. N-isopropylacrylamide and Vinyl imidazole were used as thermo and pH sensitive monomers, respectively. NarSPNPs were characterized using dynamic light scattering (DLS) analyses, SEM and FTIR for particle size and potential analysis, surface morphology and functional group determinations, respectively. Release profile and its effects on cell proliferation, apoptosis and cell cycle in breast cancer were also studied. Physicochemical characterization of newly prepared NarSPNPs, cytotoxicity, and IC50 assessments confirmed their stability and bioactivity as an anti-breast cancer agent with no toxicity against human epithelia cells. These findings together with flow cytometry analysis, revealed that apoptosis is the main mechanism underlying cell death after NarSPNPs treatment.
dc.description.sponsorshipResearch Fund of Tarsus Universityin Turkey [SHMY.21.001]
dc.description.sponsorshipThis study was supported by the Research Fund of Tarsus Universityin Turkey with Project Number: SHMY.21.001. The authors would like to thank Ms. Harmony Matshik Dakafay for English language editing of the manuscript.
dc.identifier.doi10.1016/j.jddst.2022.103552
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85133173409
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2022.103552
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2061
dc.identifier.volume74
dc.identifier.wosWOS:000826360500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectNaringenin
dc.subjectSmart nanoparticles
dc.subjectThermo sensitive polymer
dc.subjectpH sensitive polymer
dc.subjectBreast cancer
dc.titleAnti-cancer activity of naringenin loaded smart polymeric nanoparticles in breast cancer
dc.typeArticle

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