Evaluating the simultaneous electrochemical determination of antineoplastic drugs using LaNiO3/g-C3N4@RGH nanocomposite material

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dc.authorscopusid57224482924
dc.authorscopusid55348334900
dc.authorwosidDRG-0686-2022
dc.authorwosidAAK-3383-2021
dc.contributor.authorBouali, Wiem
dc.contributor.authorErk, Nevin
dc.contributor.authorSert, Buse
dc.contributor.authorHarputlu, Ersan
dc.date.accessioned2024-08-28T09:07:58Z
dc.date.available2024-08-28T09:07:58Z
dc.date.issued2024
dc.departmentFakülteler, Mühendislik Fakültesi, Mühendislik Temel Bilimleri Bölümü
dc.description.abstractA novel electrochemical sensor based on LaNiO3/g-C3N4@RGH nanocomposite material was developed to simultaneously determine Ribociclib (RIBO) and Alpelisib (ALPE). Ribociclib and Alpelisib are vital anticancer medications used in the treatment of advanced breast cancer. The sensor exhibited excellent electrocatalytic activity towards the oxidation of RIBO and ALPE, enabling their simultaneous detection. The fabricated sensor was characterized using various techniques, including energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS), which confirmed the successful synthesis of the LaNiO3/g-C3N4@RGH composite material. Electrochemical characterization revealed enhanced conductivity and lower resistance of the modified electrode compared to the bare electrode. The developed sensor exhibited high repeatability, reproducibility, stability, and selectivity toward RIBO detection. Furthermore, the sensor displayed high sensitivity with low detection limits of 0.88 nM for RIBO and 6.1 nM for ALPE, and linear ranges of 0.05–6.2 ?M and 0.5–6.5 ?M, respectively. The proposed electrochemical sensor offers a promising approach for simultaneously determining RIBO and ALPE in pharmaceutical formulations and biological samples with recovery data of 98.7–102.0 %, providing a valuable tool for anticancer drug analysis and clinical research.
dc.identifier.citationBouali, W., Erk, N., Sert, B. ve Harputlu, E. (2024). Evaluating the simultaneous electrochemical determination of antineoplastic drugs using LaNiO3/g-C3N4@RGH nanocomposite material, Talanta, 278. Erişim adresi: https://doi.org/10.1016/j.talanta.2024.126486
dc.identifier.doi10.1016/j.talanta.2024.126486
dc.identifier.endpage13en_US
dc.identifier.issn0039-9140
dc.identifier.issn1873-3573
dc.identifier.scopus2-s2.0-85197524537
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2024.126486
dc.identifier.urihttps://hdl.handle.net/20.500.13099/375
dc.identifier.volume278en_US
dc.identifier.wosWOS:001284202600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorHarputlu, Ersan
dc.institutionauthorSert, Buse
dc.language.isoen
dc.publisherElsevier
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlpelisib
dc.subjectElectrochemical sensor
dc.subjectNanocomposite material
dc.subjectPharmaceutical products
dc.subjectRibociclib
dc.titleEvaluating the simultaneous electrochemical determination of antineoplastic drugs using LaNiO3/g-C3N4@RGH nanocomposite material
dc.typeArticle

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