Evaluating the simultaneous electrochemical determination of antineoplastic drugs using LaNiO3/g-C3N4@RGH nanocomposite material

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dc.authorscopusid57224482924en_US
dc.authorscopusid55348334900en_US
dc.authorwosidDRG-0686-2022en_US
dc.authorwosidAAK-3383-2021en_US
dc.contributor.authorBouali, Wiem
dc.contributor.authorErk, Nevin
dc.contributor.authorSert, Buse
dc.contributor.authorHarputlu, Ersan
dc.date.accessioned2024-08-28T09:07:58Z
dc.date.available2024-08-28T09:07:58Z
dc.date.issued2024en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Mühendislik Temel Bilimleri Bölümüen_US
dc.description.abstractA novel electrochemical sensor based on LaNiO3/g-C3N4@RGH nanocomposite material was developed to simultaneously determine Ribociclib (RIBO) and Alpelisib (ALPE). Ribociclib and Alpelisib are vital anticancer medications used in the treatment of advanced breast cancer. The sensor exhibited excellent electrocatalytic activity towards the oxidation of RIBO and ALPE, enabling their simultaneous detection. The fabricated sensor was characterized using various techniques, including energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS), which confirmed the successful synthesis of the LaNiO3/g-C3N4@RGH composite material. Electrochemical characterization revealed enhanced conductivity and lower resistance of the modified electrode compared to the bare electrode. The developed sensor exhibited high repeatability, reproducibility, stability, and selectivity toward RIBO detection. Furthermore, the sensor displayed high sensitivity with low detection limits of 0.88 nM for RIBO and 6.1 nM for ALPE, and linear ranges of 0.05–6.2 μM and 0.5–6.5 μM, respectively. The proposed electrochemical sensor offers a promising approach for simultaneously determining RIBO and ALPE in pharmaceutical formulations and biological samples with recovery data of 98.7–102.0 %, providing a valuable tool for anticancer drug analysis and clinical research.en_US
dc.identifier.citationBouali, W., Erk, N., Sert, B. ve Harputlu, E. (2024). Evaluating the simultaneous electrochemical determination of antineoplastic drugs using LaNiO3/g-C3N4@RGH nanocomposite material, Talanta, 278. Erişim adresi: https://doi.org/10.1016/j.talanta.2024.126486en_US
dc.identifier.doi10.1016/j.talanta.2024.126486en_US
dc.identifier.endpage13en_US
dc.identifier.issn0039-9140
dc.identifier.issn1873-3573
dc.identifier.scopus2-s2.0-85197524537en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2024.126486
dc.identifier.urihttps://hdl.handle.net/20.500.13099/375
dc.identifier.volume278en_US
dc.identifier.wos001284202600001en_US
dc.identifier.wosqualityQ1en_US
dc.institutionauthorHarputlu, Ersan
dc.institutionauthorSert, Buse
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpelisiben_US
dc.subjectElectrochemical sensoren_US
dc.subjectNanocomposite materialen_US
dc.subjectPharmaceutical productsen_US
dc.subjectRibocicliben_US
dc.titleEvaluating the simultaneous electrochemical determination of antineoplastic drugs using LaNiO3/g-C3N4@RGH nanocomposite materialen_US
dc.typearticleen_US

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