Unveiling combat strategies against Candida spp. biofilm structures: Demonstration of photodynamic inactivation with innovative phthalocyanine derivatives

Basit Öğe Kaydı
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridTuncel, Ayca/0000-0003-0699-3309
dc.authoridOZTURK, ISMAIL/0000-0002-2669-3090
dc.authoridDEMIRCIOGLU, Perihan Kubra/0000-0001-9077-5990
dc.authoridOZEL, Derya/0000-0003-0596-5293
dc.contributor.authorOzturk, Ismail
dc.contributor.authorOzel, Derya
dc.contributor.authorDogan, Sifa
dc.contributor.authorTuncel, Ayca
dc.contributor.authorYurt, Fatma
dc.contributor.authorTekintas, Yamac
dc.contributor.authorDemircioglu, Perihan Kubra
dc.date.accessioned2025-03-17T12:27:03Z
dc.date.available2025-03-17T12:27:03Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractAntimicrobial resistance is an important problem for infection control and therapy. Microorganisms in biofilm structure are remarkably less susceptible to antimicrobials compared to planktonic cells. Increasing rates of resistance to antimicrobials have led to the development of new antimicrobial strategies. Antimicrobial photodynamic therapy (PDT) is an alternative treatment method that may contribute to the fields of infection control and treatment. This study aimed to investigate the antifungal activities of photosensitizers and the anti -biofilm activities of phthalocyanine derivatives on C. albicans and C. parapsilosis strains. The anti -biofilm effects of aPDT on the biofilm of Candida albicans were also visualized via SEM (Scanning Electron Microscopy). Our findings showed that aPDT with phthalocyanines inhibited biofilm production levels and reduced the mature biofilm levels of Candida strains. Additionally, SEM results supported that aPDT application successfully eradicated fungal cells and inhibited the biofilm produced by C. albicans . Although more detailed experiments are needed, we suggest that the use of Pcs in aPDT may be beneficial for the treatment of biofilm-related Candida infections.
dc.identifier.doi10.1016/j.jphotochem.2024.115746
dc.identifier.issn1010-6030
dc.identifier.issn1873-2666
dc.identifier.scopus2-s2.0-85192228942
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jphotochem.2024.115746
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2040
dc.identifier.volume454
dc.identifier.wosWOS:001239526100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofJournal of Photochemistry and Photobiology A-Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectAntimicrobial photodynamic therapy
dc.subjectCandida albicans
dc.subjectCandida parapsilosis
dc.subjectBiofilm
dc.subjectAnti -biofilm activity
dc.subjectPhthalocyanines
dc.titleUnveiling combat strategies against Candida spp. biofilm structures: Demonstration of photodynamic inactivation with innovative phthalocyanine derivatives
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu