Polyvinyl alcohol: Starch based membrane scaffolds for tissue transparency requirements: Fabrication, characterization and cytotoxicity studies

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dc.contributor.authorCeylan, Seda
dc.contributor.authorDemir, Didem
dc.date.accessioned2025-03-17T12:22:46Z
dc.date.available2025-03-17T12:22:46Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractIn this study, the characterization and cytocompatibility of polyvinyl alcohol:starch (PVA:ST) based membrane tissue scaffolds developed for tissue transparency requirements in tissue engineering applications were evaluated in the presence of sodium dodecyl sulphate (SDS). In this context, two different amounts of SDS were added to the polymer structure of transparent membrane scaffolds to roughen the surfaces of PVA:ST membranes and to promote cell adhesion. In the light of this aim, three different types of membranes were created: A constant PVA:ST ratio of 9:1 (wt:wt) was used as a control and varying amounts of SDS (2 and 4 wt% of the total polymer amount) were added to the polymer solutions. Membrane tissue scaffolds were formed by freeze-drying method. Scaffold properties such as morphology, transparency, water absorption, chemical structure and cytocompatibility were investigated. In terms of physicochemical properties, it was observed that with the addition of SDS, the membranes had a rougher surface while retaining water retention and transparency. In cytotoxicity studies, the membranes were found to be non-cytotoxic and promoted cell proliferation as assessed by MTT assay. Furthermore, the PVA:ST membrane scaffold with 4% SDS added was able to promote the attachment, migration and proliferation of Mouse Embryonic Fibroblasts (MEFs) more than the control group. Overall, the results indicate that SDS-added PVA:ST scaffold membranes are suitable for human corneal stromal regeneration, wound dressing material and neural tissue engineering applications. © 2024 The Authors
dc.identifier.doi10.1016/j.nxmate.2024.100148
dc.identifier.issn2949-8228
dc.identifier.scopus2-s2.0-85204543666
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1016/j.nxmate.2024.100148
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1368
dc.identifier.volume3
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofNext Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250316
dc.subjectPolyviniyl alcohol
dc.subjectRoughness
dc.subjectScaffold
dc.subjectSDS
dc.subjectStarch
dc.subjectTransparency
dc.titlePolyvinyl alcohol: Starch based membrane scaffolds for tissue transparency requirements: Fabrication, characterization and cytotoxicity studies
dc.typeArticle

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