Synthesis and antimicrobial photodynamic activities of axially {4-[(1E)-3-oxo-3-(2-thienyl)prop-1-en-1-yl]phenoxy} groups substituted silicon phthalocyanine, subphthalocyanine on Gram-positive and Gram-negative bacteria

Basit Öğe Kaydı
dc.authoridTuncel, Ayca/0000-0003-0699-3309
dc.authoridOZTURK, ISMAIL/0000-0002-2669-3090
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridBiyiklioglu, Zekeriya/0000-0001-5138-214X
dc.contributor.authorBiyiklioglu, Zekeriya
dc.contributor.authorOzturk, Ismail
dc.contributor.authorArslan, Tayfun
dc.contributor.authorTuncel, Ayca
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorHosgor-Limoncu, Mine
dc.contributor.authorYurt, Fatma
dc.date.accessioned2025-03-17T12:27:20Z
dc.date.available2025-03-17T12:27:20Z
dc.date.issued2019
dc.departmentTarsus Üniversitesi
dc.description.abstractToday, the problem of antimicrobial resistance is the most important cause of morbidity and mortality in the treatment of infectious diseases worldwide. Therefore, alternative treatment strategies are important for controlling infectious diseases. In the basic principle of antimicrobial photodynamic therapy (aPDT), when harmless light at the appropriate wavelength absorbed by the photosensitizer, undergoes a transition from a ground state to a triplet state. The triplet state photosensitizer can interact with enzym and substrate molecules to produce free radicals and radical ions, or with molecular oxygen resulting in the generation of singlet oxygen which leads to cell cytotoxicity of the microorganism. For this purpose, axially {4-[(1E)-3-oxo-3-(2-thienyl) prop-1-en-1-yl] phenoxy} group substituted silicon phthalocyanine (Es-SiPc) and subphthalocyanine (Es-SubPc) were synthesized by reaction of SiPcCl2, SubPcCl with (2E)-3-(4-hydroxyphenyl)-1-(2-thienyl)prop-2-en-1-one in the presence of NaH in toluene. The new Es-SiPc and Es-SubPc were characterized by standard spectroscopy methods. The effects of aPDT in the presence of phthalocyanines were investigated against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) strains. Also, singlet oxygen generation of Es-SiPc and Es-SubPc were investigated. Our results suggest that the aPDT in the presence of newly synthesized Es-SiPc and Es-SubPc has promising antibacterial effects on Gram-positive and Gram-negative bacteria.
dc.identifier.doi10.1016/j.dyepig.2019.03.010
dc.identifier.endpage158
dc.identifier.issn0143-7208
dc.identifier.issn1873-3743
dc.identifier.scopus2-s2.0-85063025870
dc.identifier.scopusqualityQ1
dc.identifier.startpage149
dc.identifier.urihttps://doi.org/10.1016/j.dyepig.2019.03.010
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2196
dc.identifier.volume166
dc.identifier.wosWOS:000466823300017
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofDyes and Pigments
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectPhthalocyanines
dc.subjectSilicon
dc.subjectAntimicrobial photodynamic therapy
dc.subjectStaphylococcus aureus
dc.subjectEscherichia coli
dc.titleSynthesis and antimicrobial photodynamic activities of axially {4-[(1E)-3-oxo-3-(2-thienyl)prop-1-en-1-yl]phenoxy} groups substituted silicon phthalocyanine, subphthalocyanine on Gram-positive and Gram-negative bacteria
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu