Investigation of in vitro activities of Cu2ZnSnS4 nanoparticles in human non-small cell lung cancer

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dc.authoridOcakoglu, Kasim/0000-0003-2807-0425
dc.authoridcolak, suleyman gokhan/0000-0002-4978-1499
dc.contributor.authorColak, Suleyman Gokhan
dc.contributor.authorSezer, Canan Vejselova
dc.contributor.authorDemirdogen, Ruken Esra
dc.contributor.authorInce, Mine
dc.contributor.authorEmen, Fatih Mehmet
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorKutlu, Hatice Mehtap
dc.date.accessioned2025-03-17T12:26:03Z
dc.date.available2025-03-17T12:26:03Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstractCu2ZnSnS4 (CZTS) nanoparticles (NPs) were prepared by a simple hydrothermal method, and their cytotoxic, antiproliferative and proapoptotic activities on human non-small cell lung adenocarcinoma A549 cells were investigated for the first time, and the morphological and ultrastructural changes of these cells were monitored. The structural characterizations of the synthesized nanoparticles were made by using Field Emission-Scanning Electron Microscope (FE-SEM), X-Ray Powder Diffraction (XRD) and Raman techniques. Cytotoxicity and confocal microscopy studies revealed that the CZTS NPs effectively entered into the A549 cells in a dose-dependent not time-dependent manner over a period of 24 and 48 h. It was observed that the CZTS NPs had a negligible cytotoxic effect and considerable antiproliferative and pmapoptotic activities. The low cytotoxicity of the CSTZ NPs and their potent anticancer activity against A549 cells highlight their potential to be used as anticancer agents. This study may pave the way for designing and constructing various morphologically diverse, nanotextured materials with desired functional attributes.
dc.identifier.doi10.1016/j.mtcomm.2021.102304
dc.identifier.issn2352-4928
dc.identifier.scopus2-s2.0-85103770304
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.mtcomm.2021.102304
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2005
dc.identifier.volume27
dc.identifier.wosWOS:000683036000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMaterials Today Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectCu2ZnSnS4
dc.subjectCZTS nanoparticle
dc.subjectCytotoxicity
dc.subjectCell death
dc.subjectLung cancer
dc.titleInvestigation of in vitro activities of Cu2ZnSnS4 nanoparticles in human non-small cell lung cancer
dc.typeArticle

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