Insights into the antioxidant and anticancer properties of novel biologically synthesized NiO/Ni2O3 nanoparticles using Sargassum tenerrimum

Basit Öğe Kaydı
dc.authoridBarwant, Mukul/0000-0002-5639-4251
dc.contributor.authorBarwant, Mukul
dc.contributor.authorKarande, Vanita
dc.contributor.authorBasnet, Parita
dc.contributor.authorKumar, Deepak
dc.contributor.authorSargazi, Saman
dc.contributor.authorMirzaei, Mahmoud
dc.contributor.authorJabir, Majid S.
dc.date.accessioned2025-03-17T12:27:35Z
dc.date.available2025-03-17T12:27:35Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractPresently, the utilization of nanomaterials has evolved as an appealing alternative for ever-changing healthcare obstacles due to their distinctive features and multifunctional applications. This work aimed to fabricate and analyze novel NiO/Ni2O3 nanoparticles (NPs) using Sargassum tentorium extracts and investigate their antioxidant and anticancer potentials. Diverse analytical instrumental tools were applied to explore NiO/Ni2O3 NPs, including UV-vis diffuse reflectance spectroscopy (UVDRS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), high-resolution scanning electron microscopy (HRTEM), and energy-dispersive X-ray (EDX) analyses. HRTEM images revealed mostly quasi-spherical and wire-shaped NPs with average 97 and 87 nm sizes for NiO/Ni2O3 NPs. Afterward, the biological properties of the biologically manufactured NiO/Ni2O3 NPs were explored. This work assessed the anticancer potential of as-fabricated NiO/Ni2O3 NPs utilizing the MTT assay. The experiment assessed cell viability at doses ranging from 7.81 to 500 mu g/mL during a 24 h period for the breast cancer cell line (MCF-7). The study outcomes demonstrate a concentration-dependent effect of fabricated NiO/Ni2O3 NPs on MCF-7 cells. The inhibition of MCF-7 cells increases with the concentration of NiO/Ni2O3 NPs, achieving an IC50 value of 883.4 mu g/mL in 24 h. Furthermore, the antioxidant potency of NiO/Ni2O3 NPs was examined via a free radical scavenging ABTS and DPPH assay. At a concentration of 50 mu g/mL, NiO/Ni2O3 NPs also exhibited 74.71% ABTS scavenging and 71.62% DPPH scavenging inhibition, respectively. In conclusion, NiO/Ni2O3 NPs manufactured via Sargassum tenerrimum extracts could be promising candidates for further biomedical applications.
dc.identifier.doi10.1007/s10971-024-06446-1
dc.identifier.endpage420
dc.identifier.issn0928-0707
dc.identifier.issn1573-4846
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85196763588
dc.identifier.scopusqualityQ2
dc.identifier.startpage409
dc.identifier.urihttps://doi.org/10.1007/s10971-024-06446-1
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2333
dc.identifier.volume111
dc.identifier.wosWOS:001253169500002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Sol-Gel Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectNickel oxide nanoparticles
dc.subjectGreen synthesis
dc.subjectSargassum tenerrimum
dc.subjectBiological activities
dc.titleInsights into the antioxidant and anticancer properties of novel biologically synthesized NiO/Ni2O3 nanoparticles using Sargassum tenerrimum
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu