Detection of N-hexanoyl-L-homoserine lactone via MIP-based QCM sensor: preparation and characterization

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dc.authoridAcet, Omur/0000-0003-1864-5694
dc.authoridODABASI, Mehmet/0000-0002-3288-132X
dc.contributor.authorAcet, Omur
dc.contributor.authorOdabasi, Mehmet
dc.date.accessioned2025-03-17T12:27:38Z
dc.date.available2025-03-17T12:27:38Z
dc.date.issued2023
dc.departmentTarsus Üniversitesi
dc.description.abstractWhile high living organisms use sounds and words to communicate with each other, bacteria provide this function with some communication molecules. These communication molecules are expressed as Quorum Sensing (QS) or chemicals produced by the environment sensing system and used by bacteria to communicate. This case revealed that bacteria are talking. N-acyl-homoserine-lactones (AHL), which are the main signaling molecules of gram-negative bacteria, may express the pathogenic factors, and Quorum Sensing (QS) system may play an important role in the identification of the being virus. AHLs are produced at low concentrations that are difficult to detect with general techniques. In this study, molecularly imprinted polymeric membranes, which are specific to lactone with 6-carbons (C6-HSL) were prepared on QCM chips, and molecularly imprinted QCM chips were utilized to detect N-hexanoyl-L-homoserine lactone (C6-HSL) with high sensitivity from the aqueous medium. Characterization of the synthesized polymers were analyzed by AFM, SEM, contact angle and FTIR-ATR spectrophotometer analyzes. The maximum C6-HSL adsorption on the C6-HSL imprinted QCM chip surface was observed at 1000 ng/mL concentration, pH 7.0. Moreover, GC-MS results correlated with the results of our studies, and they confirmed the sensitivity of synthesized polymers toward C6-HSL in solution containing competitor molecules.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [119Z184]; Aksaray University Scientific Research Projects Coordination [2018/060]
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (Grant Number:119Z184) and Aksaray University Scientific Research Projects Coordination, (Grant Number:2018/060). Authors gratefully acknowledge the use of the services and facilities of Scientific and Technological Application and Research Center of Aksaray University (ASUBTAM).
dc.identifier.doi10.1007/s00289-022-04377-x
dc.identifier.endpage6674
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85134465219
dc.identifier.scopusqualityQ1
dc.identifier.startpage6657
dc.identifier.urihttps://doi.org/10.1007/s00289-022-04377-x
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2370
dc.identifier.volume80
dc.identifier.wosWOS:000828960300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectQuartz crystal microbalance
dc.subjectMolecularly imprinted membranes
dc.subjectQuorum sensing
dc.subjectN-Acyl-homoserine-lactones
dc.titleDetection of N-hexanoyl-L-homoserine lactone via MIP-based QCM sensor: preparation and characterization
dc.typeArticle

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