Photodynamic Therapy of Oral Cancer and Novel Liposomal Photosensitizers

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dc.authoridDuzgunes, Nejat/0000-0001-6159-1391
dc.authoridPiskorz, Jaroslaw/0000-0002-4904-8502
dc.contributor.authorDuzgunes, Nejat
dc.contributor.authorPiskorz, Jaroslaw
dc.contributor.authorSkupin-Mrugalska, Paulina
dc.contributor.authorYildirim, Metin
dc.contributor.authorSessevmez, Melike
dc.contributor.authorCheung, Jennifer
dc.date.accessioned2025-03-17T12:25:13Z
dc.date.available2025-03-17T12:25:13Z
dc.date.issued2023
dc.departmentTarsus Üniversitesi
dc.description.abstractPhotodynamic therapy facilitates the selective destruction of cancer tissue by utilizing a photosensitizer drug, the light near the absorbance wavelength of the drug, and oxygen. Methylene Blue, 5-aminolevulinic acid (the precursor of the photosensitizer, protoporphyrin IX), porphyrin, Foscan, Chlorin e6, and HPPH have been used successfully as photosensitizers in the treatment of oral verrucous hyperplasia, oral leukoplakia, oral lichen planus, and head and neck squamous cell carcinoma. Theranostic liposomes can deliver a contrast agent for magnetic resonance imaging and a photosensitizer for the image-guided photodynamic therapy of head and neck cancer. Liposomes incorporating photosensitizers can be targeted to cell surface markers overexpressed on cancer cells. Novel porphyrinoids have been developed in our laboratories that are highly effective as photosensitizers. Tribenzoporphyrazines encapsulated in cationic liposomes have produced IC50 values up to 50 times lower compared to the free photosensitizers. It is anticipated that targeting these drugs to cancer stem cells, using upconversion nanoparticles for the near-infrared irradiation of tumors to activate the photosensitizers, and overcoming tumor hypoxia will enhance the efficacy of photodynamic therapy of tumors accessible to light sources.
dc.identifier.doi10.3390/oral3030023
dc.identifier.endpage294
dc.identifier.issn2673-6373
dc.identifier.issue3
dc.identifier.scopusqualityN/A
dc.identifier.startpage276
dc.identifier.urihttps://doi.org/10.3390/oral3030023
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1566
dc.identifier.volume3
dc.identifier.wosWOS:001268734000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofOral
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectoral squamous cell carcinoma
dc.subjectpharyngeal cancer
dc.subjectnanoparticles
dc.subjectphotodynamic therapy
dc.subjectphotosensitizer
dc.subjecttargeted liposomes
dc.subjectsinglet excited state
dc.subjecttheranostics
dc.subjecttribenzoporphyrazines
dc.titlePhotodynamic Therapy of Oral Cancer and Novel Liposomal Photosensitizers
dc.typeReview

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