From peripherally unsubstituted subphthalocyanines with anti-inflammatory activity on macrophages to tri-iodo derivatives with adjuvant and immunostimulatory functions

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dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.authoridInce, Mine/0000-0002-9164-0446
dc.authoridYUZER, ABDULCELIL/0000-0002-2287-4126
dc.contributor.authorAyaz, Furkan
dc.contributor.authorYuzer, Abdulcelil
dc.contributor.authorInce, Mine
dc.date.accessioned2025-03-17T12:25:34Z
dc.date.available2025-03-17T12:25:34Z
dc.date.issued2019
dc.departmentTarsus Üniversitesi
dc.description.abstractIn this study we evaluated the impact of iodine substitution on the ability of subphthalocyanines (SubPc) to stimulate or regulate the function of macrophages. Previous studies have focused on the usage of phthalocyanines and their derivatives as treatment options against different types of cancer. In order to obtain better prognosis rates, their possible effects on the immune system cells should be delineated. Unique subphthalocyanines were designed and synthesized by our group and a derivative was generated via iodine substitution. In our study we further tested the effects of the new Subpcs on macrophage cell lines. Macrophages play an important role in the immune system through cytokine production and antigen presentation to other types of the immune system cells. They can define the type and the strength of the immune responses against a particular danger signal. Based on pro-inflammatory cytokine (TNF alpha, IL1 beta and 1L6) production levels by macrophages, unsubstituted SubPc had anti-inflammatory properties. However, iodine substitution on the same SubPc created a completely opposite effect since these iodo-substituted SubPc exerted an immunostimulatory effect on macrophages based on significant increases in the pro-inflammatory cytokine production levels compared to the untreated controls. While SubPcs can be used to suppress the pro-inflammatory activities of the macrophages, iodine-substituted SubPcs have potentials to be used as adjuvants and inununostimulatory molecules.
dc.identifier.doi10.1142/S1088424618501134
dc.identifier.endpage62
dc.identifier.issn1088-4246
dc.identifier.issn1099-1409
dc.identifier.issue1-2
dc.identifier.scopus2-s2.0-85109607380
dc.identifier.scopusqualityQ3
dc.identifier.startpage56
dc.identifier.urihttps://doi.org/10.1142/S1088424618501134
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1757
dc.identifier.volume23
dc.identifier.wosWOS:000460467300007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWorld Sci Publ Co Inc
dc.relation.ispartofJournal of Porphyrins and Phthalocyanines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectmacrophages
dc.subjectinflammation
dc.subjectimmunotoxicology
dc.subjectsubphthalocyanine
dc.subjectadjuvants
dc.titleFrom peripherally unsubstituted subphthalocyanines with anti-inflammatory activity on macrophages to tri-iodo derivatives with adjuvant and immunostimulatory functions
dc.typeArticle

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