Nuclear imaging potential and in vitro photodynamic activity of Boron subphthalocyanine on colon carcinoma cells

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dc.authoridTuncel, Ayca/0000-0003-0699-3309
dc.authoridOZEL, Derya/0000-0003-0596-5293
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.contributor.authorYurt, Fatma
dc.contributor.authorArslan, Tayfun
dc.contributor.authorBiyiklioglu, Zekeriya
dc.contributor.authorTuncel, Ayca
dc.contributor.authorOzel, Derya
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-03-17T12:27:05Z
dc.date.available2025-03-17T12:27:05Z
dc.date.issued2020
dc.departmentTarsus Üniversitesi
dc.description.abstractPhotodynamic therapy (PDT) has been a promising clinical agent in various types of cancer in recent years. In this study, in vitro nuclear imaging and PDT potential of Es-SubPc (Boron subphthalocyanine) were evaluated in colon adenocarcinoma cell line (HT-29) and human healthy lung fibroblast cell line (WI-38). For this purpose, the Es-SubPc was labeled with I-131 using the iodogen method under the optimum conditions resulting in labeled with high yield (98.9 +/- 1.2%). In addition, the uptake rate of I-131-Es-SubPc was determined in HT-29 and WI-38 cell lines. In comparison to the healthy cell line, the uptake of 131I-Es-SubPc was found to be 2-fold higher in the HT-29 cell line. For PDT studies, both cells were exposed to white light at 30-90 J/cm(2) in the presence of Es-SubPc. The results showed that Es-SubPc was a good PDT agent likely to be used in HT-29 cell line. As a result, Es-SubPc can be promising nuclear imaging and PDT agent for colon carcinoma.
dc.identifier.doi10.1016/j.jddst.2020.101567
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85079380646
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2020.101567
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2063
dc.identifier.volume56
dc.identifier.wosWOS:000532688100010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectBoron subphthalocyanines
dc.subjectPhotodynamic therapy
dc.subjectColon adenocarcinoma
dc.subjectI-131
dc.titleNuclear imaging potential and in vitro photodynamic activity of Boron subphthalocyanine on colon carcinoma cells
dc.typeArticle

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