Photodynamic Anti-Inflammatory Activity of Porphyrin Derivative on In-Vitro Activated Macrophages

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dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.contributor.authorHakli, Ozgul
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorAyaz, Furkan
dc.date.accessioned2025-03-17T12:27:35Z
dc.date.available2025-03-17T12:27:35Z
dc.date.issued2023
dc.departmentTarsus Üniversitesi
dc.description.abstractPorphyrin derivatives have been known for their photodynamic therapy (PDT) application potential. In the present work, we have studied an asymmetric tetraphenyl substituted porphyrin derivative synthesized previously. Although traditional PDT applications focus on antibacterial and anti-cancer activities of the drug candidates, these compounds may have functional properties at subtoxic concentrations due to the chemically active groups that they carry. In this study, we aimed to investigate the anti-inflammatory PDT potential of this porphyrin derivative. For this purpose, mammalian macrophage cells were used. Trypan blue staining was done to confirm that this compound was effective at non-toxic concentrations. Moreover, TNF and IL6 ELISAs were done to the supernatants of the stimulated cells. Xenon light exposure was done to activate the porphyrin derivative. Our results suggest that this derivative had differential effects on these cytokine production levels by activated macrophages. These effects are light activation-dependent which makes this derivative a viable option for anti-inflammatory PDT applications. Moreover, it did not exert any cytotoxic effect at concentration used both in the dark and under light conditions.
dc.description.sponsorshipScientific Research Project (BAP) [19/087/02/1/2]; Mugla Sytky Kocman University
dc.description.sponsorshipThis work was supported in part by a Scientific Research Project (BAP) grant (Project no: 19/087/02/1/2) from Mugla Sytky Kocman University.
dc.identifier.doi10.1007/s11094-023-02913-1
dc.identifier.endpage517
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85165876049
dc.identifier.scopusqualityQ4
dc.identifier.startpage513
dc.identifier.urihttps://doi.org/10.1007/s11094-023-02913-1
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2328
dc.identifier.volume57
dc.identifier.wosWOS:001037345300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPharmaceutical Chemistry Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectInflammation
dc.subjectporphyrin
dc.subjectphotodynamic therapy
dc.subjectmacrophages
dc.subjectanti-inflammatory compounds
dc.titlePhotodynamic Anti-Inflammatory Activity of Porphyrin Derivative on In-Vitro Activated Macrophages
dc.typeArticle

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