Possible protective role of punicalagin on oxidative stress, inflammation and genotoxicity in ethanol-induced liver toxicity

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dc.authoridKONEN ADIGUZEL, Serpil/0000-0002-7959-3771
dc.contributor.authorYanpar, Esma
dc.contributor.authorYildirim, Metin
dc.contributor.authorAkkapulu, Merih
dc.contributor.authorDegirmenci, Ulas
dc.contributor.authorKonen Adiguzel, Serpil
dc.contributor.authorYalin, Serap
dc.contributor.authorYalin, Ali Erdinc
dc.date.accessioned2025-03-17T12:25:22Z
dc.date.available2025-03-17T12:25:22Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstractAlcohol consumption is a tradition in most cultures but are increasingly being arised as possessing a potential for misuse. Punicalagin is a phenolic compound that is found in forms alpha and beta in pomegranates. In this study, the protective role of punicalagin on oxidative stress, inflammation and DNA damage caused by ethanol (EtOH) in liver tissue were examined. Wistar albino rats were divided into 4 groups as control, eth, punicalagin, EtOH EtOH + punicalagin. In EtOH groups, rats were treated with EtOH (4g/kg) for 21 days, in punicalagin groups, rats were treated with punicalagin (4 mg/ kg) for 21 days. In the liver tissue, superoxide dismutase (SOD), catalase (CAT) activities and malondialdehyde (MDA) and glutathione (GSH) levels, in serum AST, ALT, LDH activities and TNF-alpha, IL-6 levels were measured. Genotoxicity was evaluated using comet assay. Based on these experimental results, while EtOH increased ALT, AST and LDH enzyme activies and induced inflammation and oxidative stress. Punicalagin reduced IL6, TNF-alpha, MDA levels, ALT, AST, LDH enzyme activities and increased SOD, CAT activities and GSH levels. EtOH significantly increased the percentage of damaged cells (type II, III and IV) and genetic damage index compared to the other groups (control, punicalagin and EtOH +punicalagin). Punicalagin was not genotoxic compared to the control. Furthermore, punicalagin reduced the genotoxic effect, induced by EtOH, with the sharp decrease in damaged cells (from 14.00 +/- 1.22 to 2.20 +/- 1.30) and genetic damage index (from 1.20 +/- 0.05 to 0.14 +/- 0.05). Punicalagin has antioxidant, anti-inflammatory and protective role against to ethanol induced liver toxicity.
dc.description.sponsorshipResearch Fund of Mersin University [2018-1-TP2-2804]
dc.description.sponsorshipAcknowledgements: This research was supported by the grants from Research Fund of Mersin University 2018-1-TP2-2804.
dc.identifier.doi10.29228/jrp.51
dc.identifier.endpage608
dc.identifier.issn2630-6344
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85115773786
dc.identifier.scopusqualityQ3
dc.identifier.startpage600
dc.identifier.trdizinid489665
dc.identifier.urihttps://doi.org/10.29228/jrp.51
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/489665
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1626
dc.identifier.volume25
dc.identifier.wosWOS:000701782800008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectPunicalagin
dc.subjectliver toxicity
dc.subjectoxidative stress
dc.subjectgenotoxicity
dc.subjectethanol
dc.titlePossible protective role of punicalagin on oxidative stress, inflammation and genotoxicity in ethanol-induced liver toxicity
dc.typeArticle

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