New Insights into Health-Promoting Effects of Nobiletin from Citrus Fruits

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dc.contributor.authorArshad, Rizwan
dc.contributor.authorMasood, Saira
dc.contributor.authorSharif, Hafiz Rizwan
dc.contributor.authorGoksen, Gulden
dc.contributor.authorXu, Baojun
dc.contributor.authorFaisal Manzoor, Muhammad
dc.date.accessioned2025-03-17T12:22:46Z
dc.date.available2025-03-17T12:22:46Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractNobiletin (NOB) is a ubiquitous phytochemical belonging to the citrus family. It is a polymethoxy flavonoid with restorative and therapeutic properties. It has excellent potential as an antioxidative, anti-inflammatory, anti-neurodegenerative, and anti-viral agent in nutrition and pharmacological studies. However, due to its lipophilic nature, different strategies to enhance its solubility, magnify physiochemical properties, and bioavailability is current interests of the researchers. NOB, after oral intake, undergoes biotransformation by the host gastrointestinal tract along with gut microbiota leading to its bioaccessibility, bioavailability, and bio-efficacy alteration. Primary NOB metabolites have been characterized and isolated successfully for their efficient biological activities. In this context, multiple studies cover the various therapeutic benefits of NOB against different diseases; however, there is an absence of a comprehensive review of NOB and its metabolites that precisely describes its chemistry, metabolism, and curative abilities. The review intends to provide emerging trends regarding NOB chemistry, metabolism, bioavailability, biotransformation, drug delivery systems to enhanced bioavailability, and therapeutic potential against different diseases such as obesity, hypertension, CVDs, cancer, diabetes, osteo, and rheumatoid arthritis, Parkinson’s and Alzheimer’s disease and its toxicity. © 2023 Taylor & Francis.
dc.description.sponsorshipGuangdong Provincial Key Laboratory of Intelligent Food Manufacturing
dc.description.sponsorshipFoshan University, FOSU
dc.description.sponsorshipBNU-HKBU United International College, (R202107)
dc.identifier.doi10.1080/87559129.2023.2212047
dc.identifier.endpage1295
dc.identifier.issn8755-9129
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85159338648
dc.identifier.scopusqualityQ1
dc.identifier.startpage1276
dc.identifier.urihttps://doi.org/10.1080/87559129.2023.2212047
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1373
dc.identifier.volume40
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofFood Reviews International
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250316
dc.subjectBioactive compound
dc.subjectbioavailability
dc.subjectchemopreventive
dc.subjectnobiletin
dc.subjectpolymethoxy flavonoids (PMFs)
dc.titleNew Insights into Health-Promoting Effects of Nobiletin from Citrus Fruits
dc.typeReview

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