THE PROTECTIVE EFFECT OF ALPHA LIPOIC ACID ON RETINAL DAMAGE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Basit Öğe Kaydı
dc.contributor.authorBerkoz, Mehmet
dc.contributor.authorYildirim, Metin
dc.contributor.authorBahar, Leyla
dc.contributor.authorSucu, Nehir
dc.contributor.authorIlhan, Mert
dc.contributor.authorYalin, Ali Erdinc
dc.date.accessioned2025-03-17T12:27:49Z
dc.date.available2025-03-17T12:27:49Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstractIn this study, we examined the effects of alpha lipoic acid treatment on streptozotocin (STZ)-induced diabetic rats and investigated the mechanisms underlying the protective action of alpha lipoic acid in diabetic retinal damage which was induced by inflammation and oxidative stress and activation of MAPKs and NF-kappa B signaling pathways. A total of 28 rats were divided into 4 groups: control, diabetes mellitus (45 mg/kg STZ, alpha lipoic acid (100 mg/kg/day, gavage, for 21 days) and diabetes mellitus+ alpha lipoic acid. We measured malondialdehyde, and reduced glutathione levels and superoxide dismutase and catalase activities, vascular endothelial growth factor, nitric oxide and prostaglandin E2 levels, inducible nitric oxide synthase and cyclooxygenase-2 mRNA levels and MAPK/NF-kappa B protein levels in retina tissue. Alpha lipoic acid enhances antioxidant enzyme activities and inhibits NF-kappa B activation and IKB-alpha degradation, phosphorylation of p38. ERK, and JNK proteins, the expression of inducible nitric oxide and cyclooxygenase-2 mRNA, and production of nitric oxide, vascular endothelial growth factor, and prostaglandin E2. These results suggest that the antioxidative and anti-inflammatory activities of alpha lipoic acid may be important mechanisms involved in the protective effect of alpha lipoic acid on diabetic retinal damage in STZ-induced diabetic rats. Furthermore. alpha lipoic acid markedly reduced retinal injury associated with diabetes, as demonstrated by reduced histological damage of retinal cells.
dc.description.sponsorshipOffice of Scientific Research Projects of Mersin University [2017-1-AP2-2208]
dc.description.sponsorshipThis research was financially supported in part by the Office of Scientific Research Projects of Mersin University under Grant number (2017-1-AP2-2208).
dc.identifier.endpage8833
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue7A
dc.identifier.scopusqualityN/A
dc.identifier.startpage8824
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2467
dc.identifier.volume30
dc.identifier.wosWOS:000678352300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectStreptozotocin
dc.subjectdiabetes
dc.subjectalpha lipoic acid
dc.subjectinflammation
dc.subjectoxidative stress
dc.subjectretinal damage
dc.titleTHE PROTECTIVE EFFECT OF ALPHA LIPOIC ACID ON RETINAL DAMAGE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu