Association of Kruppel-like factor 2 polymorphisms with the risk of coronary artery disease

Basit Öğe Kaydı
dc.authoridYALIN, Ali Erdinc/0000-0002-3351-6885
dc.authoridCICEK YILMAZ, DILEK/0000-0003-1432-8931
dc.authoridTasdelen, Bahar/0000-0001-8146-4912
dc.authoridoztornaci, Ragip Onur/0000-0002-9847-4030
dc.contributor.authorDegirmenci, Ulas
dc.contributor.authorYildirim, Metin
dc.contributor.authorAkkapulu, Merih
dc.contributor.authorYalin, Ali Erdinc
dc.contributor.authorYilmaz, Dilek Cicek
dc.contributor.authorOztornaci, Ragip Onur
dc.contributor.authorTasdelen, Bahar
dc.date.accessioned2025-03-17T12:25:25Z
dc.date.available2025-03-17T12:25:25Z
dc.date.issued2023
dc.departmentTarsus Üniversitesi
dc.description.abstractPurpose: Coronary artery disease is defined as complications that develop in proportion to the prevalence of ischemia due to occlusion of the coronary arteries and the resulting cell death. The development of atherosclerosis is significantly influenced by endothelial cell dysfunction. Kruppel-like factor 2, a transcription factor, has been shown to regulate critical biological events in endothelial biology, such as vascular tone, migration, proliferation, vasoreactivity, and angiogenesis. In our study, it was aimed to clarify the relationship between coronary artery disease and Kruppel-like factor 2 protein levels and C1239A polymorphisms.Materials and Methods: 191 individuals who underwent coronary angiography at Mersin University Faculty of Medicine, Department of Cardiology, Health, Research and Application Center were included in the study. Measurements of serum fasting blood glucose, HDL cholesterol, total cholesterol, and triglyceride levels were performed on the AU5800 (Beckman Coulter, United States) autoanalyzer. Serum LDL levels were calculated using the Friedwald equation. Serum Kruppel-like factor 2 protein levels were measured by sandwich enzyme-linked immunoassay method on the Multiskan GO (Thermo Scientific, Finland) device. Kruppel-like factor 2 C1239A variations were detected on the Applied Biosystem VIIATM 7 Real-Time PCR (Life Technologies Co., United States) device by TaqMan (R) single nucleotide polymorphism (SNP) genotyping method.Results: Men had a 3.8-fold higher risk of CAD than women. (Odd's ratio 3.83, 95% Confidence interval 1.98- 7.39; p<0.001). Kruppel-Like Factor 2 protein levels werenot significantly different amongst the groups. Kruppel-like factor 2 C1239A polymorphisms were not associated with coronary artery disease.Conclusion: More comprehensive studies with larger sample groups including other gene regions and meta -analysis studies are needed to determine the relationship between Kruppel-like factor 2 gene polymorphisms and coronary artery disease.
dc.description.sponsorshipResearch Foundation of Mersin University, Mersin, Turkey [2018-2]
dc.description.sponsorshipAcknowledgement: This research was supported by the Research Foundation of Mersin University, Mersin, Turkey (Grant no. 2018-2
dc.identifier.doi10.17826/cumj.1283236
dc.identifier.endpage592
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2
dc.identifier.scopusqualityN/A
dc.identifier.startpage583
dc.identifier.trdizinid1197748
dc.identifier.urihttps://doi.org/10.17826/cumj.1283236
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1197748
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1673
dc.identifier.volume48
dc.identifier.wosWOS:001038321300030
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectcoronary artery . Coronary artery disease
dc.subjectatherosclerosis
dc.subjectendothel
dc.subjectkruppel-like factor 2
dc.subjectsingle nucleotide polymorphism
dc.titleAssociation of Kruppel-like factor 2 polymorphisms with the risk of coronary artery disease
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu