Enhanced bacterial uptake of 131I-labeled antimicrobial imidazolium bromide salts using fluorescent carbon nanodots

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dc.authoridcolak, suleyman gokhan/0000-0002-4978-1499
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridOZTURK, ISMAIL/0000-0002-2669-3090
dc.authoridGenc, Rukan/0000-0002-9569-8776
dc.authoridTuncel, Ayca/0000-0003-0699-3309
dc.contributor.authorDuman, Ali Niyazi
dc.contributor.authorColak, Suleyman Gokhan
dc.contributor.authorAlas, Melis Ozge
dc.contributor.authorEr, Ozge
dc.contributor.authorTuncel, Ayca
dc.contributor.authorOzturk, Ismail
dc.contributor.authorYurt, Fatma
dc.date.accessioned2025-03-17T12:26:03Z
dc.date.available2025-03-17T12:26:03Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstractImidazolium bromide salts have been shown as potent antibiotic molecules that show structure-based bioactivity related to their cation alkyl side chain length. To enhance the bioavailability of lipophilic alkyl side chains herein, a 1,8-naphthalimide group containing imidazolium bromide salts bearing different lengths of alkyl chains (NIM1, 2, and 3) are coupled with fluorescent carbon dots (C-NIMs) through electrostatic and pi-pi interactions. Further, obtained nanocarriers were radio-labeled with iodine-131 (I-131) to track the bacterial uptake of them by Staphylococcus aureus and Escherichia coli. Antibacterial activities were also investigated by the microdilution method. Comparison studies showed that both radiolabeling efficiency and lipophilicity increased when NIMs were integrated onto the CDots. More importantly, CDots resulted in 4-fold enhanced uptake of NIM1 by S. aureus bacterium as compared to pristine imidazolium bromide salts while at a higher number of alkyl chain lengths enhancement was 2-fold.
dc.identifier.doi10.1016/j.mtcomm.2021.102167
dc.identifier.issn2352-4928
dc.identifier.scopus2-s2.0-85101572008
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.mtcomm.2021.102167
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2006
dc.identifier.volume26
dc.identifier.wosWOS:000634314700002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMaterials Today Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectCarbon dots
dc.subjectImidazolium salts
dc.subjectNaphthalimide
dc.subjectAntibacterial activity
dc.subjectRadiolabelling
dc.subjectGram-positive bacteria
dc.titleEnhanced bacterial uptake of 131I-labeled antimicrobial imidazolium bromide salts using fluorescent carbon nanodots
dc.typeArticle

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