Beyond the Conventional Photodynamic Therapy by Water-Soluble Phthalocyanines

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dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.authoridYUZER, ABDULCELIL/0000-0002-2287-4126
dc.authoridDEMIRCIOGLU, Perihan Kubra/0000-0001-9077-5990
dc.contributor.authorYuzer, Lecturer Abdulcelil
dc.contributor.authorDemircioglu, Perihan Kubra
dc.contributor.authorYetkin, Lecturer Derya
dc.contributor.authorInce, Mine
dc.contributor.authorAyaz, Furkan
dc.date.accessioned2025-03-17T12:27:41Z
dc.date.available2025-03-17T12:27:41Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractCompared to the classical chemotherapy applications, PDT applications are based on a non-toxic compound that can be specifically activated by shining a certain wavelength of light. Constitituvely active chemotherapy drug agents lead to detrimental and unwanted side effects that halt the normal life standards of the cancer patients. Localized and controlled activation of the drug agents by PDT applications aims to overcome the side effects associated with the treatment. In our study we synthesized a unique set of phthalocyanine molecules that are water soluble to make them biocompatible. Moreover, these compounds anti-cancer activities were measured from multiple angles. Anti-cancer PDT activities of the derivatives were studied by testing their effects on the cell proliferation, apoptosis and cell cycle progression. Moreover, these derivatives anti-metastatic, anti-angiogenic and immunomodulatory photodynamic activities were comprehensively studied by focusing on the intracellular signaling pathways that may play important roles in carcinogenesis, angiogenesis, metastasis and immune reactions. For the first time to our knowledge we are presenting data beyond the classical or canonical PDT applications in which generation of the reactive oxygen species (ROS) is explained as the main mechanism of the action for the PDT applications. Our results suggest that non-canonical PDT activity can be observed independent of the ROS generation efficiencies probably by affecting the intracellular signaling pathways. These novel set of phthalocyanine derivatives may find applications against colon, lung, breast and prostate cancer.
dc.description.sponsorshipTuBTAK, Turkey [1001, 119Z354]
dc.description.sponsorshipFinancial support by TuBTAK, Turkey (1001 project with the 119Z354 ID number), is gratefully acknowledged.
dc.identifier.doi10.1002/slct.202202532
dc.identifier.issn2365-6549
dc.identifier.issue36
dc.identifier.scopus2-s2.0-85139218582
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202202532
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2390
dc.identifier.volume7
dc.identifier.wosWOS:000856039700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectAngiogenesis
dc.subjectImmune system
dc.subjectMetastasis
dc.subjectPhthalocyanine
dc.subjectPhotodynamic Therapy
dc.titleBeyond the Conventional Photodynamic Therapy by Water-Soluble Phthalocyanines
dc.typeArticle

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