DETERMINATION OF MALIGNANT MELANOMA BY ANALYSIS OF VARIATION VALUES

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dc.contributor.authorEsim, Ahmet Kürşat
dc.contributor.authorKaya, Hilal
dc.contributor.authorAlcan, Veysel
dc.date.accessioned2025-03-17T12:22:54Z
dc.date.available2025-03-17T12:22:54Z
dc.date.issued2019
dc.departmentTarsus Üniversitesi
dc.description.abstractMelanoma is a serious disease associated with mutation-based cancer cells. Genetic structure and hereditary condition play important role to understand the underlying reasons of the diseases caused by Deoxiribole Nucleic Acid (DNA). In order to identify mutation carriers and to analyze disease, researchers tend to find various gene determinations methods. Nowadays, Next Generation Sequencing (NGS) is emerging as a valuable and powerful platform to detect gene-based diseases by entiring human genome. In this study, we aimed to propose a bioinformatics application workflow to distinguish between insertions/deletions and somatic/germline mutations, by using NGS methods. We carried this study out on a data set containing 100 human genomes data (20 training, 80 testing) for the detection of Malignant Melanoma. We found that the results of diagnosis performance were 92.50% accuracy, 94.03% precision, 96.92% sensitivity and 95.45% F1 score. These results show the potential for proposed application based on NGS to improve Melanoma detection. © 2019, Murat Yakar. All rights reserved.
dc.identifier.doi10.31127/tuje.472328
dc.identifier.endpage126
dc.identifier.issn2587-1366
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85167368625
dc.identifier.scopusqualityQ3
dc.identifier.startpage120
dc.identifier.trdizinid358334
dc.identifier.urihttps://doi.org/10.31127/tuje.472328
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/358334
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1465
dc.identifier.volume3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMurat Yakar
dc.relation.ispartofTurkish Journal of Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250316
dc.subjectBurrows-Wheeler Transform
dc.subjectMalignant Melanoma
dc.subjectNext Generation Sequencing
dc.subjectVariant Calling
dc.titleDETERMINATION OF MALIGNANT MELANOMA BY ANALYSIS OF VARIATION VALUES
dc.typeArticle

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