Anti-Inflammatory Effects of Coumarin-Selenophene Derivatives on LPS-Stimulated RAW 264.7 Macrophage Cells

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dc.authoridErsatir, Mehmet/0000-0003-1077-0626
dc.contributor.authorYildirim, M.
dc.contributor.authorUnal, Z. N.
dc.contributor.authorErsatir, M.
dc.contributor.authorYetkin, D.
dc.contributor.authorDegirmenci, U.
dc.contributor.authorGiray, E. S.
dc.date.accessioned2025-03-17T12:25:35Z
dc.date.available2025-03-17T12:25:35Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractCoumarin and coumarin derivatives have been known for their anti-viral, anti-oxidant, anti-cancer and anti-inflammatory activities. Changes in biological activity when these biologically active compounds are combined with different heterocyclic groups are among the topics of interest to researchers in recent years. Therefore, a series of coumarin-selenophene hybrid compounds have been synthesized. Products are fully characterized by NMR and FT-IR spectroscopic techniques. The prepared compounds are screened for their anti-inflammatory potencies on LPS induced mouse macrophage cell line (RAW 264.7). The results showed that coumarin-selenophene hybrid compounds were not cytotoxic at the tested concentrations on RAW 264.7 macrophages. Also, these compounds decreased TNF- alpha, IL-6 secretion, and NO, PGE(2) production in dose-depended manner. According to our results, coumarin-selenophene hybrid compounds have the capacity to moderate the immune response and a potential anti-inflammatory activity.
dc.description.sponsorship(Scientific Research Committee of Mersin University) [2021-1-AP4-4227]
dc.description.sponsorshipThe research leading to these results received funding from (Scientific Research Committee of Mersin University) under Grant Agreement no. 2021-1-AP4-4227.
dc.identifier.doi10.1134/S1068162022060279
dc.identifier.endpage1214
dc.identifier.issn1068-1620
dc.identifier.issn1608-330X
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85140253253
dc.identifier.scopusqualityQ4
dc.identifier.startpage1209
dc.identifier.urihttps://doi.org/10.1134/S1068162022060279
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1769
dc.identifier.volume48
dc.identifier.wosWOS:000870655000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMaik Nauka/Interperiodica/Springer
dc.relation.ispartofRussian Journal of Bioorganic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectcoumarin
dc.subjectselenophene
dc.subjectinflammation
dc.subjectmacrophage
dc.subjectsynthesis
dc.titleAnti-Inflammatory Effects of Coumarin-Selenophene Derivatives on LPS-Stimulated RAW 264.7 Macrophage Cells
dc.typeArticle

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