The Role of Glutathione S-Transferases in Pleomorphic Adenomas of the Salivary Glands

Basit Öğe Kaydı
dc.contributor.authorAtlı, Muharrem
dc.contributor.authorÇetin, Sema
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorBaşak, Kayhan
dc.contributor.authorAydın, Sedat
dc.contributor.authorYılmaz, Can
dc.contributor.authorAnıl, Gizem Kat
dc.date.accessioned2025-03-16T12:43:13Z
dc.date.available2025-03-16T12:43:13Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description2020/035
dc.description.abstractThe aim of this study is to determine the expression levels of GST isoenzymes in salivary gland pleomorphic adenoma from 26 patients. In this study, we investigated the immunohistochemical staining characteristics of the Glutathione-S-transferase alpha (GSTA-1), sigma (GSTS-1), theta (GSTT-1), kappa (GSTK-1), mu (GSTM-1), omega (GSTO-1) isoenzymes in tumor and surrounding tumor-free (normal) salivary gland tissues from 26 patients. For immunohistochemical studies, tissues were obtained from 26 patients with salivary gland pleomorphic adenoma (PA). Tumor and control tissues of patients were compared according to their staining intensity. The correlations between GST expressions in PA tissue were analyzed by Spearman’s rho and the clinicopathological data were examined by Mann Whitney-U test and Spearman’s rho. Considering the differences in the expressions of GST isoenzymes between tumor tissues and normal tissues of the patients; No differences in GSTT1 and GSTS1 isoenzymes expression were found between tumor and normal tissues (p>0.05). GSTM1 and GSTO1 expression were significantly higher in tumor tissues than in normal tissue. However, GSTK1 and GSTA1 expressions were found to be significantly higher in the normal tissues of the patients compared to the tumor tissues. GSTM1 and GSTO1 expressions were increased in salivary gland PAs. These results should be confirmed with a larger series and different enzyme subtypes.
dc.description.sponsorshipKırıkkale University Scientific Research and Projects Department
dc.identifier.doi10.47947/ijnls.1072427
dc.identifier.issn2602-2478
dc.identifier.issn2602-2397
dc.identifier.issue1
dc.identifier.startpage45627
dc.identifier.urihttps://doi.org/10.47947/ijnls.1072427
dc.identifier.urihttps://hdl.handle.net/20.500.13099/624
dc.identifier.volume6
dc.language.isoen
dc.publisherUğur ÇAKILCIOĞLU
dc.relation.ispartofInternational Journal of Nature and Life Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250316
dc.subjectSalivary gland
dc.subjectPleomorphic adenoma
dc.subjectGlutathione S-Transferase
dc.subjectImmunohistochemistry
dc.titleThe Role of Glutathione S-Transferases in Pleomorphic Adenomas of the Salivary Glands
dc.typeArticle

Dosyalar

Koleksiyon

Öksüz Yayınlar