Evaluation of photodynamic therapy and nuclear imaging potential of subphthalocyanine integrated TiO2 nanoparticles in mammary and cervical tumor cells

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dc.authoridAvci, Cigir Biray/0000-0001-8251-4520
dc.authoridInce, Mine/0000-0002-9164-0446
dc.authoridcolak, suleyman gokhan/0000-0002-4978-1499
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authoridSoylu, Hale Melis/0000-0001-8253-8346
dc.contributor.authorYurt, Fatma
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorEr, Ozge
dc.contributor.authorSoylu, Hale Melis
dc.contributor.authorInce, Mine
dc.contributor.authorAvci, Cigir Biray
dc.contributor.authorKurt, Cansu Caliskan
dc.date.accessioned2025-03-17T12:25:34Z
dc.date.available2025-03-17T12:25:34Z
dc.date.issued2019
dc.departmentTarsus Üniversitesi
dc.description.abstractThis study, subphthalocyanines (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc-TiO2) were synthesized as novel photosensitizers. Their PDT effects were evaluated. Furthermore, nuclear imaging potential of I-131-labelled SubPc/SubPc-TiO2 were examined in mouse mammary carcinoma (EMT6) and cervix adenocarcinoma (HeLa) cell lines. The uptake results show that SubPc labelled with I-131 radionuclide ((131) I-SubPc) in EMT6 and HeLa cell lines was found to be approximately the same as in the WI38 cell line. However, the uptake values of SubPc-TiO2 labelled with I-131(I-131-SubPc- TiO2) in EMT6 and HeLa cell lines were determined to be two times higher than in the WI38 cell line. In other words, the target/non-target tissue ratio was identified as two in the EMT6 and HeLa cell lines. I-131-SubPc-TiO2 is promising for imaging or treatment of breast and cervix tumors. In vitro photodynamic therapy studies have shown that SubPc and SubPc-TiO2 are suitable agents for PDT. In addition, SubPc-TiO2 has higher phototoxicity than SubPc. As a future study, in vivo experiments will be held and performed in tumor-bearing nude mice.
dc.description.sponsorshipScientific and Technological Research Council of Turkey, TUBITAK [114Z430]
dc.description.sponsorshipThe authors gratefully acknowledge financial support by The Scientific and Technological Research Council of Turkey, TUBITAK (Grant no: 114Z430).
dc.identifier.doi10.1142/S1088424619500639
dc.identifier.endpage915
dc.identifier.issn1088-4246
dc.identifier.issn1099-1409
dc.identifier.issue7-8
dc.identifier.scopus2-s2.0-85109635006
dc.identifier.scopusqualityQ3
dc.identifier.startpage908
dc.identifier.urihttps://doi.org/10.1142/S1088424619500639
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1755
dc.identifier.volume23
dc.identifier.wosWOS:000484115800018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWorld Sci Publ Co Inc
dc.relation.ispartofJournal of Porphyrins and Phthalocyanines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectsubphthalocyanine
dc.subjectphotodynamic therapy
dc.subjectnuclear imaging
dc.subjecttitanium nanoparticle
dc.titleEvaluation of photodynamic therapy and nuclear imaging potential of subphthalocyanine integrated TiO2 nanoparticles in mammary and cervical tumor cells
dc.typeArticle

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