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    A comprehensive review of the bioactive components of sesame seeds and their impact on bone health issues in postmenopausal women
    (Royal Soc Chemistry, 2023) Arooj, Ammara; Rabail, Roshina; Naeem, Muhammad; Goksen, Gulden; Xu, Baojun; Aadil, Rana Muhammad
    Sesame seeds perform many therapeutic functions against several health issues especially those related to bones because they possess a rich content of calcium, vitamins, proteins, oil, and carbohydrates. Using the PubMed, ScienceDirect, and Google Scholar databases, we performed a comprehensive search of the literature from 2013 to date on reports related to sesame seeds and their bioactive ingredients. Sesamin, sesamol, sesamolin, and sesamol are the major bioactive lignans found in sesame seeds. Our comprehensive review of the literature revealed the protective role of sesame seeds towards bone health in postmenopausal osteoporosis. It was observed that sesame seeds have a positive impact on postmenopausal women experiencing bone-related problems, i.e. osteoporosis and arthritis. Therefore, this review is focused on exploring the effect of sesame seeds on bone mineralization in women experiencing menopause. Furthermore, to aid balancing the hormones in women after their disturbance by the postmenopausal phase, we highlight the effect of the daily intake of sesame seeds in women. Finally, we conclude that the supplementation of sesame seeds in a regular diet shows a positive impact on the bone health of post-menopausal osteoporosis.
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    New Insights into Health-Promoting Effects of Nobiletin from Citrus Fruits
    (Taylor and Francis Ltd., 2024) Arshad, Rizwan; Masood, Saira; Sharif, Hafiz Rizwan; Goksen, Gulden; Xu, Baojun; Faisal Manzoor, Muhammad
    Nobiletin (NOB) is a ubiquitous phytochemical belonging to the citrus family. It is a polymethoxy flavonoid with restorative and therapeutic properties. It has excellent potential as an antioxidative, anti-inflammatory, anti-neurodegenerative, and anti-viral agent in nutrition and pharmacological studies. However, due to its lipophilic nature, different strategies to enhance its solubility, magnify physiochemical properties, and bioavailability is current interests of the researchers. NOB, after oral intake, undergoes biotransformation by the host gastrointestinal tract along with gut microbiota leading to its bioaccessibility, bioavailability, and bio-efficacy alteration. Primary NOB metabolites have been characterized and isolated successfully for their efficient biological activities. In this context, multiple studies cover the various therapeutic benefits of NOB against different diseases; however, there is an absence of a comprehensive review of NOB and its metabolites that precisely describes its chemistry, metabolism, and curative abilities. The review intends to provide emerging trends regarding NOB chemistry, metabolism, bioavailability, biotransformation, drug delivery systems to enhanced bioavailability, and therapeutic potential against different diseases such as obesity, hypertension, CVDs, cancer, diabetes, osteo, and rheumatoid arthritis, Parkinson’s and Alzheimer’s disease and its toxicity. © 2023 Taylor & Francis.
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    Role of AuNPs in Active Food Packaging Improvement: A Review
    (Mdpi, 2022) Ahari, Hamed; Fakhrabadipour, Mostafa; Paidari, Saeed; Goksen, Gulden; Xu, Baojun
    There is a worldwide concern about food loss due to reduced shelf life among food science researchers. Hence, it seems that any techniques contributing to improved food packaging are most welcome in the food sector. It has been demonstrated that the administration of nanotechnology-based techniques such as metal-based nanoparticles can fade away the unresolved obstacles in shortened shelf life and environmental concerns. Along with substantial signs of progress in nanoscience, there is a great interest in the usage of green synthesis-based methods for gold nanoparticles as the most advantageous metals, when compared to conventional chemistry-based methods. Interestingly, those aforementioned methods have significant potential to simplify targeted administration of gold nanoparticles due to a large surface-volume ratio, and diminished biohazards, aimed at increasing stability, and induction of anti-microbial or antioxidant properties. However, it is necessary to consider the hazards of gold nanoparticles including migration for food packaging purposes.