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[Cell@Al2O3(HEPiPY)]DCA: A Cellulose Supported Ionic Liquid Catalyst for Synthesis of 11 b,12-dihydro-6H,13Hbenzo[5,6][1,3]oxazino[3,4-a]quinazoline-6,13-dione along with in silico assessments
(Wiley-V C H Verlag Gmbh, 2024) Shinde, Vikas B.; Mhaldar, Pradeep M.; Patil, Mayuri V.; Mirzaei, Mahmoud; Pore, Dattaprasad M.
In present study we have designed and synthesized novel cellulose supported ionic liquid catalyst (CSILC), [Cell@Al2O3(HEPiPY)]DCA and explored its catalytic efficiency for synthesis of novel 11b,12-dihydro-6H,13Hbenzo[5,6][1,3]oxazino[3,4-a]quinazoline-6,13-diones by performing the one pot reaction of 2-(2-hydroxyaryl)-2,3- dihydroquinazolin-4(1H)-one and 1,1-carbonyl diimidazole (CDI). The catalyst was characterized by diverse analytical techniques viz. Fourier-Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Analysis (EDX) and Thermo Gravimetric Analysis (TGA). The biological activities of synthesized novel derivatives were evaluated along with in silico assessments against the vascular endothelial growth factor receptor-2 (VEGFR-2) target, in which the results were considerable. The catalyst exhibited remarkable reusability up to six consecutive runs without considerable loss in the catalytic activity.