Yazar "Kumar, Deepak" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Insights into the antioxidant and anticancer properties of novel biologically synthesized NiO/Ni2O3 nanoparticles using Sargassum tenerrimum
    (Springer, 2024) Barwant, Mukul; Karande, Vanita; Basnet, Parita; Kumar, Deepak; Sargazi, Saman; Mirzaei, Mahmoud; Jabir, Majid S.
    Presently, the utilization of nanomaterials has evolved as an appealing alternative for ever-changing healthcare obstacles due to their distinctive features and multifunctional applications. This work aimed to fabricate and analyze novel NiO/Ni2O3 nanoparticles (NPs) using Sargassum tentorium extracts and investigate their antioxidant and anticancer potentials. Diverse analytical instrumental tools were applied to explore NiO/Ni2O3 NPs, including UV-vis diffuse reflectance spectroscopy (UVDRS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), high-resolution scanning electron microscopy (HRTEM), and energy-dispersive X-ray (EDX) analyses. HRTEM images revealed mostly quasi-spherical and wire-shaped NPs with average 97 and 87 nm sizes for NiO/Ni2O3 NPs. Afterward, the biological properties of the biologically manufactured NiO/Ni2O3 NPs were explored. This work assessed the anticancer potential of as-fabricated NiO/Ni2O3 NPs utilizing the MTT assay. The experiment assessed cell viability at doses ranging from 7.81 to 500 mu g/mL during a 24 h period for the breast cancer cell line (MCF-7). The study outcomes demonstrate a concentration-dependent effect of fabricated NiO/Ni2O3 NPs on MCF-7 cells. The inhibition of MCF-7 cells increases with the concentration of NiO/Ni2O3 NPs, achieving an IC50 value of 883.4 mu g/mL in 24 h. Furthermore, the antioxidant potency of NiO/Ni2O3 NPs was examined via a free radical scavenging ABTS and DPPH assay. At a concentration of 50 mu g/mL, NiO/Ni2O3 NPs also exhibited 74.71% ABTS scavenging and 71.62% DPPH scavenging inhibition, respectively. In conclusion, NiO/Ni2O3 NPs manufactured via Sargassum tenerrimum extracts could be promising candidates for further biomedical applications.
  • [ X ]
    Öğe
    Insights into the promising heterogeneous catalysis of eco-friendly synthesized spinel CuFe2O4 nanoparticles for Biginelli reaction
    (Springer, 2024) Sanap, Dnyaneshwar; Avhad, Lata; Ahire, Satish; Mirzaei, Mahmoud; Kumar, Deepak; Ghotekar, Suresh; Gaikwad, Nitin D.
    Spinel copper ferrite magnetic nanoparticles (CuFe2O4 MNPs) are one of the prominent spinel ferrites due to their magnetic properties. As a result of the current investigation, the magnetic spinel copper ferrite nanoparticles (CuFe2O4 MNPs) were successfully fabricated via a green synthesis approach using freshly prepared Yogurt of cow milk as a capping agent by sol-gel auto-combustion route and its catalytic effect towards synthesizing ethyl 1,2,3,4-tetrahydro-2-oxo-4-aryl pyrimidine-5-carboxylate (DHPMs) scaffold was explored. Further, the phase formation, crystallinity, particle size, grain morphology, and the property of magnetism of bio-fabricated spinel CuFe2O4 NPs were explored by XRD, FESEM, EDX, FTIR, UVDRS, and VSM analysis. Furthermore, one-pot synthesis of DHPMs scaffold via multicomponent (MCR) Biginelli reaction was examined using biosynthesized spinel CuFe2O4 magnetic heterogeneous catalyst (C1 and C2 nanocrystalline phase). To achieve the high yields (90-98%) of DHPMs scaffold synthesis with an extensive range of aromatic carbaldehyde using minimum loading of heterogeneous catalysts within minimum reaction time and easy catalyst recovery by a peripheral magnet were examined. Therefore, this protocol presents an extensive scope for Biginelli reaction using magnetically separable heterogeneous catalyst synthesis via a green approach.