Yazar "Emen, Fatih Mehmet" seçeneğine göre listele

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    Öğe
    Development of Ruthenium Oxide Modified Polyethersulfone Membranes for Improvement of Antifouling Performance Including Decomposition Kinetic of Polymer
    (Springer, 2023) Yigit, Basak; Ozay, Yasin; Emen, Fatih Mehmet; Kutlu, Emine; Ocakoglu, Kasim; Dizge, Nadir
    In this study, RuO2-embedded PES membrane was prepared and it was used for protein separation. The antifouling properties of the fabricated composite membranes were also investigated using bovine serum albumin (BSA) as protein solution. The mean roughness increased proportionally by introducing RuO2 particles. The porosity of the composite membranes was higher than that of the pristine PES membrane. On the other hand, composite membranes has smaller average pore size after addition of RuO2 particles. The blending of RuO2 particles to the PES membrane caused to increase the hydrophilicity. The contact angle was measured 76.67 +/- 1.21 degrees, 73.23 +/- 0.84 degrees, 70.28 +/- 0.77 degrees, and 67.13 +/- 0.80 degrees for pristine PES, PES/RuO2 0.50 wt%., PES/RuO2 0.75 wt%., and PES/RuO2 1.00 wt%, respectively. The pure water flux of the membranes decreased from 439.7 to 379.3 L/m(2)/h for the pristine PES and PES/RuO2 1.00 wt%. The pore size was calculated as 16.47 nm for the pristine PES and pore size decreased up to 6.05 nm when RuO2 particles increased up to 1.00 wt%. BSA fluxes were 84.1 +/- 2.1, 86.3 +/- 2.5, and 93.9 +/- 3.2 L/m(2)/h for pristine, PES/RuO2 0.50 wt%, and PES/RuO2 0.75 wt% membranes, respectively. PES/RuO2 1.00 wt%. membrane supplied the lowest BSA flux (73.6 +/- 3.1 L/m(2)/h). BSA rejection efficiencies increased from 45.5 +/- 1.8% to 92.6 +/- 1.5% when blended RuO2 particles increased from 0 to 1.00 wt%. The results depicted that R-ir values decreased while R-r values increased after the blending of RuO2. The thermal studies of the PES/RuO2 membranes were also performed by DTA/TG. The Activation Energy (E-a) values of the PES/RuO2 membranes were found to be 57.67-641.34 kJ/mol for Flynn-Wall-Ozawa (FWO) and 55.13-659.10 kJ/mol for Kissenger-Akahira-Sunose (KAS).
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    Öğe
    Investigation of in vitro activities of Cu2ZnSnS4 nanoparticles in human non-small cell lung cancer
    (Elsevier, 2021) Colak, Suleyman Gokhan; Sezer, Canan Vejselova; Demirdogen, Ruken Esra; Ince, Mine; Emen, Fatih Mehmet; Ocakoglu, Kasim; Kutlu, Hatice Mehtap
    Cu2ZnSnS4 (CZTS) nanoparticles (NPs) were prepared by a simple hydrothermal method, and their cytotoxic, antiproliferative and proapoptotic activities on human non-small cell lung adenocarcinoma A549 cells were investigated for the first time, and the morphological and ultrastructural changes of these cells were monitored. The structural characterizations of the synthesized nanoparticles were made by using Field Emission-Scanning Electron Microscope (FE-SEM), X-Ray Powder Diffraction (XRD) and Raman techniques. Cytotoxicity and confocal microscopy studies revealed that the CZTS NPs effectively entered into the A549 cells in a dose-dependent not time-dependent manner over a period of 24 and 48 h. It was observed that the CZTS NPs had a negligible cytotoxic effect and considerable antiproliferative and pmapoptotic activities. The low cytotoxicity of the CSTZ NPs and their potent anticancer activity against A549 cells highlight their potential to be used as anticancer agents. This study may pave the way for designing and constructing various morphologically diverse, nanotextured materials with desired functional attributes.