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    Enhanced bacterial uptake of 131I-labeled antimicrobial imidazolium bromide salts using fluorescent carbon nanodots
    (Elsevier, 2021) Duman, Ali Niyazi; Colak, Suleyman Gokhan; Alas, Melis Ozge; Er, Ozge; Tuncel, Ayca; Ozturk, Ismail; Yurt, Fatma
    Imidazolium bromide salts have been shown as potent antibiotic molecules that show structure-based bioactivity related to their cation alkyl side chain length. To enhance the bioavailability of lipophilic alkyl side chains herein, a 1,8-naphthalimide group containing imidazolium bromide salts bearing different lengths of alkyl chains (NIM1, 2, and 3) are coupled with fluorescent carbon dots (C-NIMs) through electrostatic and pi-pi interactions. Further, obtained nanocarriers were radio-labeled with iodine-131 (I-131) to track the bacterial uptake of them by Staphylococcus aureus and Escherichia coli. Antibacterial activities were also investigated by the microdilution method. Comparison studies showed that both radiolabeling efficiency and lipophilicity increased when NIMs were integrated onto the CDots. More importantly, CDots resulted in 4-fold enhanced uptake of NIM1 by S. aureus bacterium as compared to pristine imidazolium bromide salts while at a higher number of alkyl chain lengths enhancement was 2-fold.
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    Öğe
    Synthesis of new water-soluble ionic liquids and their antibacterial profile against gram-positive and gram-negative bacteria
    (Elsevier Sci Ltd, 2019) Duman, Ali Niyazi; Ozturk, Ismail; Tuncel, Ayca; Ocakoglu, Kasim; Colak, Suleyman Gokhan; Hosgor-Limoncu, Mine; Yurt, Fatma
    A series of imidazolium bromide salts (NIM-Br 1a, 1b and 1c) bearing different lengths of alkyl chains were synthesized and theirin vitro antibacterial activities were determined by measuring the minimum inhibitory concentration (MIC) values for Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Enterococcus faecalis. In addition, these imidazolium derivatives were also evaluated against biofilm produced by these bacterial strains. All compounds were found to be effective against Gram-positive and Gram-negative bacteria, and also more effective on the S. aureus biofilm production than the others.