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Öğe Anti-Inflammatory Effects of Coumarin-Selenophene Derivatives on LPS-Stimulated RAW 264.7 Macrophage Cells(Maik Nauka/Interperiodica/Springer, 2022) Yildirim, M.; Unal, Z. N.; Ersatir, M.; Yetkin, D.; Degirmenci, U.; Giray, E. S.Coumarin and coumarin derivatives have been known for their anti-viral, anti-oxidant, anti-cancer and anti-inflammatory activities. Changes in biological activity when these biologically active compounds are combined with different heterocyclic groups are among the topics of interest to researchers in recent years. Therefore, a series of coumarin-selenophene hybrid compounds have been synthesized. Products are fully characterized by NMR and FT-IR spectroscopic techniques. The prepared compounds are screened for their anti-inflammatory potencies on LPS induced mouse macrophage cell line (RAW 264.7). The results showed that coumarin-selenophene hybrid compounds were not cytotoxic at the tested concentrations on RAW 264.7 macrophages. Also, these compounds decreased TNF- alpha, IL-6 secretion, and NO, PGE(2) production in dose-depended manner. According to our results, coumarin-selenophene hybrid compounds have the capacity to moderate the immune response and a potential anti-inflammatory activity.
